Acknowledgements

List of publications where BIU facilities were utilized. Please note that if you have used BIU equipment or other services for your publication, you are expected to acknowledge BIU in your article and inform us about your publication.

2013

Anisimov, A., Tvorogov, D., Alitalo, A., Leppänen, V.-M., An, Y., Han, E.C., Orsenigo, F., Gaal, E.I., Holopainen, T., Koh, Y.J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Ylä-Herttuala, S., Dejana, E., Koh, G.Y., Choi, C., Saharinen, P., Alitalo, K. Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis. Circulation. 2013; 127:424-34.

Kaivosoja, E., Suvanto, P., Barreto, G., Aura, S., Soininen, A., Franssila, S., Konttinen, Y.T. Cell adhesion and osteogenic differentiation on three-dimensional pillar surfaces. Journal of Biomedical Materials Research Part A. 2013; 101A:842-52.

Koch, S., Scifo, E., Rokka, A., Trippner, P., Lindfors, M., Korhonen, R., Corthals, G.L., Virtanen, I., Lalowski, M., Tyynelä, J. Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain. Neurobiology of Disease. 2013; 50:107-19.

Koivuniemi, R., Mäkelä, J., Hokkanen, M.-E., Bruelle, C., Ho, T.H., Ola, R., Korhonen, L., Schröder, J., Kataoka, H., Lindholm, D. Hepatocyte Growth Factor Activator Inhibitor-1 Is Induced by Bone Morphogenetic Proteins and Regulates Proliferation and Cell Fate of Neural Progenitor Cells. PLoS One. 2013; 8:e56117.

Mikkonen, L., Hirvonen, J., Jänne, O.A. SUMO-1 Regulates Body Weight and Adipogenesis via PPAR gamma in Male and Female Mice. Endocrinology. 2013; 154:698-708.

Moore, H.M., Bai, B., Matilainen, O., Colis, L., Peltonen, K., Laiho, M. Proteasome Activity Influences UV-Mediated Subnuclear Localization Changes of NPM. PLoS One. 2013; 8:e59096.

Nuutila, K., Peura, M., Suomela, S., Hukkanen, M., Siltanen, A., Harjula, A., Vuola, J., Kankuri, E. Recombinant human collagen III gel for transplantation of autologous skin cells in porcine full-thickness wounds. Journal of Tissue Engineering and Regenerative Medicine. 2013:n/a-n/a.

Scifo, E., Szwajda, A., Debski, J., Uusi-Rauva, K., Kesti, T., Dadlez, M., Gingras, A.-C., Tyynelä, J., Baumann, M.H., Jalanko, A., Lalowski, M. Drafting the CLN3 Protein Interactome in SH-SY5Y Human Neuroblastoma Cells: A Label-free Quantitative Proteomics Approach. Journal of Proteome Research. 2013; 12:2101-15.

Ylivinkka, I., Hu, Y., Chen, P., Rantanen, V., Hautaniemi, S., Nyman, T.A., Keski-Oja, J., Hyytiäinen, M. Netrin-1 induced activation of Notch signaling mediates glioblastoma cell invasion. Journal of Cell Science. 2013.

2012

Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A. Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice. Cell Metab. 2012; 15:100-109.

Band AM, Laiho M. SnoN oncoprotein enhances estrogen receptor-a transcriptional activity. Cell Signal. 2012; 24:922-930.

Blom T, Li Z, Bittman R, Somerharju P, Ikonen E. Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case. Traffic. 2012; 13:1234-1243.

Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res. 2012; 72:3512-3521.

Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst. 2012; 104:461-475.

Hölttä-Vuori M, Vainio S, Kauppi M, Van Eck M, Jokitalo E, Ikonen E. Endosomal Actin Remodeling by Coronin-1A Controls Lipoprotein Uptake and Degradation in Macrophages. Circ Res. 2012; 110:450-455.

Hongisto H, Vuoristo S, Mikhailova A, Suuronen R, Virtanen I, Otonkoski T, Skottman H. Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture. Stem Cell Res. 2012; 8:97-108.

Hu Y, Ylivinkka I, Chen P, Li L, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiäinen M. Netrin-4 promotes glioblastoma cell proliferation through integrin ß4 signaling. Neoplasia. 2012; 14:219-227.

Hyrskyluoto A, Reijonen S, Kivinen J, Lindholm D, Korhonen L. GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Exp Cell Res. 2012; 318:33-42.

Jansson LC, Louhivuori L, Wigren HK, Nordström T, Louhivuori V, Castrén ML, Åkerman KE. Brain-derived neurotrophic factor increases the motility of a particular N-methyl-D-aspartate /GABA-responsive subset of neural progenitor cells. Neuroscience. 2012; 224:223-234.

Järvinen PM, Myllärniemi M, Liu H, Moore HM, Leppäranta O, Salmenkivi K, Koli K, Latonen L, Band A, Laiho M. Cysteine-rich protein 1 is Regulated by Transforming Growth Factor-ß1 and Expressed in Lung Fibrosis. J Cell Physiol. 2012; 227:2605-2612.

Jäämaa S, Sankila A, Rantanen V, Peltonen K, Järvinen PM, Af Hällström TM, Ruutu M, Taari K, Andersson LC, Laiho M. Contrasting DNA Damage Checkpoint Responses in Epithelium of the Human Seminal Vesicle and Prostate. Prostate. 2012; 72:1060-1070.

Karhemo PR, Ravela S, Laakso M, Ritamo I, Tatti O, Mäkinen S, Goodison S, Stenman UH, Hölttä E, Hautaniemi S, Valmu L, Lehti K, Laakkonen P. An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis. J Proteomics. 2012; 77:87-100.

Kinnari TJ, Lampikoski H, Hyyrynen T, Aarnisalo AA. Bacterial biofilm associated with chronic laryngitis. Arch Otolaryngol Head Neck Surg. 2012; 138:467-70.

Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, Viisanen H, Åkerman KE, Lindstedt K, Pertovaara A. Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol Res. 2012; 65:149-158.

Kovac B, Teo JL, Mäkelä TP, Vallenius T. Assembly of non-contractile dorsal stress fibers requires a-actinin-1 and Rac1 in migrating and spreading cells. J Cell Sci. 2012; 126:263-73

Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O. Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8mnd: implications to delayed myelination and oligodendrocyte maturation. Neuropathol Appl Neurobiol. 2012; 38:471-486.

Lampikoski H, Aarnisalo AA, Jero J, Kinnari TJ. Mastoid biofilm in chronic otitis media. Otol Neurotol. 2012; 33:785-8.

Lavilla-Alonso S, Bauer MM, Abo-Ramadan U, Ristimäki A, Halavaara J, Desmond RA, Wang D, Escutenaire S, Ahtiainen L, Saksela K, Tatlisumak T, Hemminki A, Pesonen S. Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development. Cancer Gene Ther. 2012; 19:126-134.

Nissilä E, Ohsaki Y, Weber-Boyvat M, Perttilä J, Ikonen E, Olkkonen VM. ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion. Biochim Biophys Acta. 2012; 1821:1472-1484.

Nokisalmi P, Rajecki M, Pesonen S, Escutenaire S, Soliymani R, Tenhunen M, Ahtiainen L, Hemminki A. Radiation-Induced Upregulation of Gene Expression from Adenoviral Vectors Mediated by DNA Damage Repair and Regulation. Int J Radiat Oncol Biol Phys. 2012; 83:376-384.

Ola R, Lefebvre S, Braunewell KH, Sainio K, Sariola H. The expression of Visinin-like 1 during mouse embryonic development. Gene Expr Patterns. 2012; 12:53-62.

Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci USA. 2012; 109:E388-97.

Peura M, Kaartinen I, Suomela S, Hukkanen M, Bizik J, Harjula A, Kankuri E, Vuola J. Improved skin wound epithelialization by topical delivery of soluble factors from fibroblast aggregates. Burns 2012; 38:541-550.

Pitkonen M, Abo-Ramadan U, Marinkovic I, Pedrono E, Hasan KM, Strbian D, Durukan A, Tatlisumak T. Long-term evolution of diffusion tensor indices after temporary experimental ischemic stroke in rats. Brain Res. 2012; 1445:103-110.

Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C. Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. PLoS One. 2012; 7:e46212.

Sarek G, Ma L, Enbäck J, Järviluoma A, Moreau P, Haas J, Gessain A, Koskinen PJ, Laakkonen P, Ojala PM. Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene. 2012; Epub ahead of print.

Sarparanta J, Jonson PH, Golzio C, Sandell S, Luque H, Screen M, McDonald K, Stajich JM, Mahjneh I, Vihola A, Raheem O, Penttilä S, Lehtinen S, Huovinen S, Palmio J, Tasca G, Ricci E, Hackman P, Hauser M, Katsanis N, Udd B. Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. Nat Genet. 2012; 44:450–455.

Sillat T, Saat R, Pöllänen R, Hukkanen M, Takagi M, Konttinen YT. Basement membrane collagen type IV expression by human mesenchymal stem cells during adipogenic differentiation. J Cell Mol Med. 2012; 16:1485-95.

Tamminen JA, Myllärniemi M, Hyytiäinen M, Keski-Oja J, Koli K. Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling. J Cell Biochem. 2012; 113:2234-2247

Tervaniemi MH, Siitonen HA, Söderhäll C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J, Elomaa O. Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization. PLoS One. 2012; 7:e49920.

Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A. Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. Int J Cancer 2012; 131:1032-41.

Uusi-Rauva K, Kyttälä A, van der Kant R, Vesa J, Tanhuanpää K, Neefjes J, Olkkonen VM, Jalanko A. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012; 69:2075-2089.

Zou J, Poe D, Ramadan UA, Pyykkö I. Oval window transports Gd-DOTA from the rat middle ear to the vestibulum and scala vestibuli shown by in vivo MRI. Ann Oto Rhinol Laryn. 2012; 121:119-128.

Zou J, Sood R, Ranjan S, Poe D, Ramadan UA, Pyykkö I, Kinnunen PK. Size-dependent passage of liposome nanocarriers with preserved posttransport integrity across the middle-inner ear barriers in rats. Otol Neurotol. 2012; 33:666-673.

2011

Tammela T, Saaristo A, Holopainen T, Ylä-Herttuala S, Andersson LC, Virolainen S, Immonen I,Alitalo K. Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis. Sci Transl Med. 2011 Feb 9;3(69)

Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-Herttuala S, Ballmer-Hofer K, Alitalo K. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood. 2011 Feb 3;117(5):1507-15. Epub 2010 Dec 8.

Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet. 2011 Jun;7(6):e1002119. Epub 2011 Jun 9.

Karhemo, P-R., Rivinoja, A., Lundin, J., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M., Heikkilä, P., Joensuu, H., Bono, P. and Laakkonen, P. An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer. Am. J. Pathol. 2011;179(2):1004-14.

Mattila OS, Strbian D, Saksi J, Pikkarainen TO, Rantanen V, Tatlisumak T, Lindsberg PJ. Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation. Stroke 2011 Dec;42(12):3600-5. Epub 2011 Oct 6.

Moore HM, Bai B, Boisvert FM, Latonen L, Rantanen V, Simpson JC, Pepperkok R, Lamond AI, Laiho M. Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Mol Cell Proteomics. 2011 Oct;10(10):M111.009241. Epub 2011 Jul 21.

Latonen L, Moore HM, Bai B, Jäämaa S, Laiho M. Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability. Oncogene. 2011 Feb 17;30(7):790-805. Epub 2010 Oct 18.

Tuuminen, R., Syrjälä, S., Krebs, R., Keränen, M.A.I., Koli, K., Abo-Ramadan, U., Nykänen, A.I. and Lemström K.B.: Donor simvastatin treatment abolishes rat cardiac allograft ischemia-reperfusion injury and chronic rejection through microvascular protection. Circulation , 2011;124:1138-1150

Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol. 2011 Sep 11;13(10):1202-13.

Hernández M, Gamonal J, Salo T, Tervahartiala T, Hukkanen M, Tjäderhane L, Sorsa T. Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice. J Periodontal Res 2011;46:58-66.

Tatti O, Arjama M, Ranki A, Weiss SJ, Keski-Oja J, Kaisa Lehti. (2011) Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion. PLoS ONE 6(12): e28325. doi:10.1371/journal.pone.0028325

Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K. Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. Blood. 2011 Jul 28;118(4):1154-62. Epub 2011 May 12.

Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A. Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. Int J Cancer. 2011 Oct 27. doi: 10.1002/ijc.27331. [Epub ahead of print]

Lavilla-Alonso S, Abo-Ramadan U, Halavaara J, Escutenaire S, Tatlisumak T, Saksela K, Kanerva A, Hemminki A, Pesonen S. Optimized mouse model for the imaging of tumor metastasis upon experimental therapy. PLOS ONE 2011; 6(11), e26810.

Marjamaa J, Antell H, Abo-Ramadan U, Hernesniemi JA, Niemelä MR, Kangasniemi M. High-resolution TOF MR angiography at 4.7 Tesla for volumetric and morphologic evaluation of coiled aneurysm neck remnants in a rat model. Acta Radiol 2011;52:340-8.

Planagumà P, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M. Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma. Hum Pathol 2011;42:57-67.

Vihervaara T, Uronen RL, Wohlfahrt G, Björkhem I, Ikonen E, Olkkonen VM. Sterol binding by OSBP-related protein 1L regulates late endosome motility and function. Cell Mol Life Sci 2011;68:537-51.

Zou J, Yoshida T, Ramadan UA, Pyykkö I. Dynamic enhancement of the rat inner ear after ultra-small-volume administration of Gd-DOTA to the medial wall of the middle ear cavity. ORL J Otorhinolaryngol Relat Spec 2011;73:275-81.

Alan E. Renton, Elisa Majounie, Adrian Waite, Javier Simón-Sánchez, Sara Rollinson, J. Raphael Gibbs, Jennifer C. Schymick, Hannu Laaksovirta, John C. van Swieten, Liisa Myllykangas, Hannu Kalimo, Anders Paetau, Yevgeniya Abramzon, Anne M. Remes, Alice Kaganovich, Sonja W. Scholz, Jamie Duckworth, Jinhui Ding, Daniel W. Harmer, Dena G. Hernandez, Janel O. Johnson, Kin Mok, Mina Ryten, Danyah Trabzuni, Rita J. Guerreiro, Richard W. Orrell, James Neal, Alex Murray, Justin Pearson, Iris E. Jansen, David Sondervan, Harro Seelaar, Derek Blake, Kate Young, Nicola Halliwell, Janis Bennion Callister, Greg Toulson, Anna Richardson, Alex Gerhard, Julie Snowden, David Mann, David Neary, Michael A. Nalls, Terhi Peuralinna, Lilja Jansson, Veli-Matti Isoviita, Anna-Lotta Kaivorinne, Maarit Hölttä-Vuori, Elina Ikonen, Raimo Sulkava, Michael Benatar, Joanne Wuu, Adriano Chió, Gabriella Restagno, Giuseppe Borghero, Mario Sabatelli, The ITALSGEN Consortium, David Heckerman, Ekaterina Rogaeva, Lorne Zinman, Jeffrey D. Rothstein, Michael Sendtner, Carsten Drepper, Evan E. Eichler, Can Alkan, Ziedulla Abdullaev, Svetlana D. Pack, Amalia Dutra, Evgenia Pak, John Hardy, Andrew Singleton, Nigel M. Williams, Peter Heutink, Stuart Pickering-Brown, Huw R. Morris, Pentti J. Tienari, and Bryan J. Traynor. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD. Neuron 2011;72:257-268

Anna Meuronen. The role of inflammation and matrix proteins in airway remodelling. Helsinki University Biomedical Dissertations 2011

Camilla Norrmén, Tuomas Tammela, Tatiana V. Petrova and Kari Alitalo. Biological Basis of Therapeutic Lymphangiogenesis. Circulation 2011;123:1335-1351

Chiara Procaccini, Teemu Aitta-aho, Külli Jaako-Movits, Alexander Zharkovsky, Anne Panhelainen, Rolf Sprengel, Anni-Maija Linden and Esa R. Korpi. Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice. European Journal of Neuroscience 2011;33:161-174

Fang Cheng, Pirita Pekkonen, Simonas Laurinavicius, Nami Sugiyama, Stephen Henderson, Thomas Günther, Ville Rantanen, Elisa Kaivanto, Mervi Aavikko, Grzegorz Sarek, Sampsa Hautaniemi, Peter Biberfeld, Lauri Aaltonen, Adam Grundhoff, Chris Boshoff, Kari Alitalo, Kaisa Lehti, and Päivi M. Ojala. KSHV-Initiated Notch Activation Leads to Membrane-Type-1MatrixMetalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition . Cell Host & Microbe 2011;10:577-590

Ilkka Liikanen, Vladia Monsurrò, Laura Ahtiainen, Mari Raki, Tanja Hakkarainen, Iulia Diaconu, Sophie Escutenaire, Otto Hemminki, João D Dias, Vincenzo Cerullo, Anna Kanerva, Sari Pesonen, Daniela Marzioni, Marco Colombatti and Akseli Hemminki. Induction of Interferon Pathways Mediates In Vivo Resistance to Oncolytic Adenovirus. Molecular Therapy 2011;19:10:1858-1866

Karoliina Vuoriluoto, Gunilla Högnäs, Pipsa Meller, Kaisa Lehti, Johanna Ivaska. Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP. Matrix Biology 2011;30:207-217

Maria Sundvik, Hisaaki Kudo, Pauliina Toivonen, Stanislav Rozov, Yu-Chia Chen, and Pertti Panula. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB Journal 2011;25:4338-4347

Maurice Jansen . Using fluorescent and non-fluorescent sterols to study rafts and intracellular cholesterol transport in mammalian cells. Helsinki University Biomedical Dissertations 2011

Maurice Jansen, Yuki Ohsaki, Laura Rita Rega, Robert Bittman, Vesa M. Olkkonen and Elina Ikonen. Role of ORPs in Sterol Transport from Plasma Membrane to ER and Lipid Droplets in Mammalian Cells. Traffic 2011;12:218-231

Noora Putkonen, Jyrki P. Kukkonen, Guiseppa Mudo, Jaana Putula, Natale Belluardo, Dan Lindholm and Laura Korhonen. Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus. European Journal of Neuroscience 2011;34:1212-1221

Pauliina Porola. Sex steroids in Sjögren's syndrome. Helsinki University Biomedical Dissertations 2011

Pernilla von Nandelstadh, Rabah Soliymani, Marc Baumann and Olli Carpen. Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations. Biochemical Journal 2011;436:113-121

Roxana Ola, Madis Jakobson, Jouni Kvist, Nina Perälä, Satu Kuure, Karl-Heinz Braunewell, Darren Bridgewater, Norman D. Rosenblum, Dmitri Chilov, Tiina Immonen, Kirsi Sainio, and Hannu Sariola. The GDNF Target Vsnl1 Marks the Ureteric Tip. Journal of the American society of nephrology 2011;22:274-284

Sari Jäämaa. DNA damage recognition in the normal epithelium of human prostate and seminal vesicles. Helsinki University Biomedical Dissertations 2011

Satu Massinen, Marie-Estelle Hokkanen, Hans Matsson, Kristiina Tammimies, Isabel Tapia-Páez, Vanina Dahlström-Heuser, Juha Kuja-Panula, Jan Burghoorn, Kristian E. Jeppsson, Peter Swoboda, Myriam Peyrard-Janvid, Rune Toftgård, Eero Castrén, Juha Kere. Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons. PLoS One 2011;6:6:e20580

Wenbin Zhong, You Zhou, Shiqian Li, Tianhong Zhou, Hongling Ma, Kunde Wei, Hongye Li, Vesa M. Olkkonen, Daoguang Yana. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Experimental Cell Research 2011;317:2353-2363

2010

Ahonen MT, Diaconu I, Pesonen S, Kanerva A, Baumann M, Parviainen ST, Spiller B, Cerullo V, Hemminki A. Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5. PLoS One 2010;5(9).

Antell H, Numminen J, Abo-Ramadan U, Niemelä MR, Hernesniemi JA, Kangasniemi M. Optimization of high-resolution USPIO magnetic resonance imaging at 4.7 T using novel phantom with minimal structural interference. J Magn Reson Imaging 2010;32:1184-96.

Blom T, Bäck N, Mutka AL, Bittman R, Li Z, de Lera A, Kovanen PT, Diczfalusy U, Ikonen E. FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circ Res 2010;106:720-9.

Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, Mervaala E, Andersson LC, Knuuti J, Alitalo K. VEGF-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak or inflammation. Circulation 2010;122:1725-33.

Bäck N, Rajagopal C, Mains RE, Eipper BA. Secretory granule membrane protein recycles through multivesicular bodies. Traffic 2010;11:972-86.

Enzerink A, Rantanen V, Vaheri A. Fibroblast nemosis induces angiogenic responses of endothelial cells. Exp Cell Res 2010;316:826-35.

Guse K, Sloniecka M, Diaconu I, Ottolino-Perry K, Tang N, Ng C, Le Boeuf F, Bell JC, McCart JA, Ristimäki A, Pesonen S, Cerullo V, Hemminki A. Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models. J Virol 2010;84:856-66.

Hamer G, Matilainen O, Holmberg CI. A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nature Methods 2010;7:473-8.

Hölttä-Vuori M, Salo TV, Nyberg L, Brackmann C, Enejder A, Panula P, and Ikonen E (2010) Zebrafish: gaining popularity in lipid research. Biochem J 2010: 429: 235-242.

Jäämaa S, Af Hällström TM, Sankila A, Rantanen V, Koistinen H, Stenman UH, Zhang Z, Yang Z, De Marzo AM, Taari K, Ruutu M, Andersson LC, Laiho M. DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. Cancer Res 2010;70:8630-41.

Kaivosoja E, Myllymaa S, Kouri VP, Myllymaa K, Lappalainen R, Konttinen YT. Enhancement of silicon using micro-patterned surfaces of thin films. Eur Cell Mater 2010;19:147-57.

Lavilla-Alonso S, Bauerschmitz G, Abo-Ramadan U, Halavaara J, Escutenaire S, Diaconu I, Tatlisumak T, Kanerva A, Hemminki A, Pesonen S. Adenoviruses with an avß integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases. J Transl Med 2010;8:80.

Leppäranta O, Pulkkinen V, Koli K, Vähätalo R, Salmenkivi K, Kinnula VL, Heikinheimo M, Myllärniemi M. Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2010;42:626-32.

Myllymaa S, Kaivosoja E, Myllymaa K, Sillat T. Korhonen H, Lappalainen R, Konttinen YT. Adhesion, spreading and osteogenic differentiation of mesenchymal stem cells cultured on micropatterned diamond, titanium, tantalum and chromium coating. J Mater Sci Mater Med 2010;21:329-41.

Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV. Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood 2010;115:906-9.

Pedrono E, Durukan A, Strbian D, Marinkovic I, Shekhar S, Pitkonen M, Abo-Ramadan U, Tatlisumak T. An optimized mouse model for transient ischemic attack. J Neuropathol Exp Neurol 2010;69:188-95.

Poduval P, Sillat T, Virtanen I, Dabagh-Meshin M, Konttinen YT. Immigration check for neutrophils in RA lining: laminin α5 low expression regions act as exit point. Scand J Rheumatol 2010;39:132-40.

Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT, Eklund KK. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One 2010;5:e11765.

Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Gene Dev 2010; 24: 875-80.

Sarek G, Järviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P, Laiho M, Ojala PM. Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PLoS Pathog 2010;6:e1000818.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K. FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci USA 2010;107:15786-91.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Ingvarsen S, Engelholm LH, Kallioniemi O, Alitalo K, Taipale J, Keski-Oja J, Lehti K. FGF receptor-4 regulates tumor invasion by coupling FGF-signaling to extracellular matrix degradation. Cancer Res, 2010;70:7851-61.

Takkunen M, Hukkanen M, Liljeström M, Grenman R, Virtanen I. Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia. J Cell Mol Med 2010;14:1569-93.

Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell 2010;18:630-40.

Uronen RL, Lundmark P, Orho-Melander M, Jauhiainen M, Larsson K, Siegbahn A, Wallentin L, Zethelius B, Melander O, Syvänen AC, Ikonen E. Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels. Arterioscler Thromb Vasc Biol 2010;30:1614-20.

Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, Olkkonen VM. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. Exp Cell Res 2010;316:3304-16.

Zou J, Zhang W, Poe D, Zhang Y, Ramadan UA, Pyykkö I. Differential passage of gadolinium through the mouse inner ear barriers evaluated with 4.7 T MRI. Hear Res 2010;259:36-43.

Zou J, Ramadan UA, Pyykkö I. Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane. Otol Neurotol 2010;31:637-41.

Zou J, Sood R, Ranjan S, Poe D, Ramadan UA, Kinnunen PK, Pyykkö I. Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium. J Nanobiotechnology 2010;18:8:32.

Zou J, Zhang W, Poe D, Qin J, Fornara A, Zhang Y, Ramadan UA, Muhammed M, Pyykkö I. MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear. Nanomedicine (Lond) 2010;5:739-54.

2009

Abo-Ramadan U, Durukan A, Pitkonen M, Marinkovic I, Tatlisumak E, Pedrono E, Soinne L, Strbian D, Tatlisumak T. Post-ischemic leakiness of the blood-brain barrier: A quantitative and systematic assessment by Patlak plots. Exp Neurol 2009;219:328-33.

Ainola M, Li TF, Mandelin J, Hukkanen M, Choi SJ, Salo J, Konttinen YT. Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. Ann Rheum Dis 2009;68:427-34.

Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-Herttuala S, Alitalo K. Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res 2009;104:1302-12.

Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J, Ojala PM. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathog 2009;5:e1000324.

Durukan A, Marinkovic I, Strbian D, Pitkonen M, Pedrono E, Soinne L, Abo-Ramadan U, Tatlisumak T. Post-ischemic blood-brain barrier leakage in rats: one-week follow-up by MRI. Brain Res 2009;1280:158-65.

Koski A, Rajecki M, Guse K, Kanerva A, Ristimäki A, Pesonen S, Escutenaire S, Hemminki A. Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells. J Gene Med 2009;11:966-77.

Lehti K, Rose N, Valavaara S, Weiss SJ, Keski-Oja J. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J Cell Science 2009;122:126-35.

Linden AM, Johnson BG, Trokovic N, Korpi ER, Schoepp DD. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology 2009;57:172-82.

Linder MD, Mäyränpää MI, Peränen J, Pietilä TE, Pietiäinen VM, Uronen RL, Olkkonen VM, Kovanen PT, Ikonen E. Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages. Arterioscler Thromb Vasc Biol 2009;29:883-8.

Marincovic I, Strbian D, Pedrono E, Vekovischeva O, Shekhar S, Durukan A, Korpi E, Abo-Ramadan U, Tatlisumak T. Decompressive craniectomy for intracerebral hemorrhage: the earlier the better. Neurosurgery 2009;65:780-6.

Marjamaa J, Tulamo R, Frösen J, Abo-Ramadan U, Hernesniemi J, Niemelä M, Kangasniemi M. Occlusion of neck remnant in experimental rat aneurysms after treatment with platinum or PGLA-coated coils. Surg Neurol 2009;71:458-65.

Norrmén C, Ivanov K, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin H, Ylä-Herttuala S, Alitalo K, Petrova T. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biology 2009;185:439-57.

Perttilä J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpää K, Grimard V, Taskinen MR, Thiele C, Salomaa V, Jula A, Perola M, Virtanen I, Peltonen L, Olkkonen VM. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med 2009; 87:825-35.

Poduval P, Sillat T, Virtanen I, Porola P, KonttinenYT. Abnormal basement membrane type IV collagen alpha chain composition in labial salivary glands in Sjögren’s syndrome. Arthritis Rheum 2009;60:938-45, 2009.

Poe D, Zou J, Zhang W, Qin J, Ramadan UA, Fornara A, Muhmmed M, Pyykkö I. MRI of the cochlea with superparamagnetic iron oxide nanoparticlescompared to Gadolinium chelate contrast agents in a rat model. Eur J Nanomedicine 2009;2:29-36.

Rajecki M, af Hällström T.M, Hakkarainen T, Nokisalmi P, Hautaniemi S, Nieminen A.I, Tenhunen M, Desmond R.M, Chen D.T, Guse K, Stenman U-H, Gargini R, Kapanen M, Klefström J, Kanerva A, Pesonen S, Hemminki A. Mre11 Inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. Int J Cancer 2009;125:2441-9.

Sallinen V, Torkko V, Sundvik M, Reenilä I, Khrustalyov D, Kaslin J, Panula P. MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. J Neurochem 2009;108:719-31.

Sillat T, Pöllänen R, Lopes JRC, Porola P, Ma G, Korhonen M, Konttinen YT. Intracrine androgenic apparatus in human bone marrow stromal cells. J Cell Mol Med 2009;13:3296-3302.

Sobota JA, Bäck N, Eipper BA, Mains RE. Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. J Cell Sci 2009;122:3542-53.

Spaan M, Porola P, Laine M, Rozman B, Azuma M, Konttinen YT. Healthy human salivary glands contain a DHEA-sulphate processing intracrine machinery, which is deranged in primary Sjögren’s syndrome. J Cell Mol Med 2009;13:1261-70.

Vuoristo S, Virtanen I, Takkunen M, Palgi J, Kikkawa Y, Rousselle P, Sekiguchi K, Tuuri T, Otonkoski T. Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support. J Cell Mol Med 2009;13:2622-33.

2008

Ahola S, Myllytie P, Österberg M, Teerinen T, Laine J. Effect of polymer adsorption on cellulose nanofibril water binding capacity and aggregation. Bio Res 2008;3:1315-28.

Ainola M, Valleala H, Nykänen P, Risteli J, Hanemaaijer R, Konttinen YT. Erosive arthritis in a patient with pycnodysostosis: an experiment of nature. Arthritis Rheum 2008;58:3394-401.

Beklen A, Hukkanen M, Richardson R, Konttinen YT. Immunohistochemical localization of toll-like receptors 1-10 in periodontitis. Oral Microbiol Immunol 2008;23:425-31.

Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol 2008;84:701-12.

Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K. Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol 2008;28:4843-50.

Hölttä-Vuori M, Uronen RL, Repakova J, Salonen E, Vattulainen I, Panula P, Li Z, Bittman R, Ikonen E. BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms. Traffic 2008;9:1839-49.

Jacobs S, Ruusuvuori E, Sipilä ST, Haapanen A, Damkier HH, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatikainen LM, Tyynelä J, Praetorius J, Voipio J, Hübner CA. Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci USA 2008;8;105:311-6.

Jansen M, Pietiäinen VM, Pölönen H, Rasilainen L, Koivusalo M, Ruotsalainen U, Jokitalo E, Ikonen E. Cholesterol substitution increases the structural heterogeneity of caveolae. J Biol Chem 2008;283:14610-8.

Kantola A, Keski-Oja J, Koli K. Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion. Exp Cell Res 2008;314:2488-500.

Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, Oresic M, Alitalo K. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res 2008;103:1018-26.

Koli K, Ryynänen M, Keski-Oja J. Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells. Bone 2008;43:679-88.

Laine M, Virtanen I, Porola P, Rotar Z, Rozman B, Poduval P, Konttinen YT. Acinar epithelial cell laminin-receptors in labial salivary glands in Sjögren’s syndrome. Clin Exp Rheumatol 2008;26:807-13.

Latonen L, Järvinen PM, Laiho M. Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death. Exp Cell Res 2008;314:738-47.

Laulajainen M, Muranen T, Carpén O, Grönholm M. Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton. Oncogene 2008;27:3233-43.

Lyly A, Marjavaara SK, Kyttälä A, Uusi-Rauva K, Luiro K, Kopra O, Martinez LO, Tanhuanpää K, Kalkkinen N, Suomalainen A, Jauhiainen M, Jalanko A. Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism. Hum Mol Genet 2008;17:1406-17.

Mattila J, Kallijärvi J, Puig O. RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc Natl Acad Sci USA 2008;105:14873-8.

Otonkoski T, Banerjee M, Korsgren O, Thornell LE, Virtanen I. Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation. Diabetes Obes Metab 2008;10 Suppl 4:119-27.

Partanen S, Haapanen A, Kielar C, Pontikis C, Alexander N, Inkinen T, Saftig P, Gillingwater TH, Cooper JD, Tyynelä J. Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis. J Neuropathol Exp Neurol 2008;67:16-29.

Reijonen S, Putkonen N, Nørremølle A, Lindholm D, Korhonen L. Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins. Exp Cell Res 2008;314:950-60.

Strbian D, Durukan A, Pitkonen M, Marinkovic I, Tatlisumak E, Pedrono E, Abo-Ramadan U, Tatlisumak T. The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia. Neuroscience 2008;153:175-81.

Takkunen M, Ainola M, Vainionpää N, Grenman R, Patarroyo M, García de Herreros A, Konttinen YT, Virtanen I. Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells. Histochem Cell Biol 2008;130:509-25.

Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008;454:656-60.

Varjosalo M, Björklund M, Cheng F, Syvänen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J. Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 2008;133:537-48.

Vilen ST, Nyberg P, Hukkanen M, Sutinen M, Ylipalosaari M, Bjartell A, Paju A, Haaparanta V, Stenman UH, Sorsa T, Salo T. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. Exp Cell Res 2008;314:914-26.

Virtanen I, Banerjee M, Palgi J, Korsgren O, Lukinius A, Thornell LE, Kikkawa Y, Sekiguchi K, Hukkanen M, Konttinen YT, Otonkoski T. Blood vessels of human islets of Langerhans are surrounded by a double basement membrane. Diabetologia 2008;51:1181-91.

Väänänen AJ, Salmenperä P, Hukkanen M, Miranda KM, Harjula A, Rauhala P, Kankuri E. Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide. Free Radic Biol Med 2008;45:749-55.

2007

Beklen A, Ainola M, Hukkanen M, Gürgan C, Sorsa T. Konttinen YT. MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. J Dent Res 2007;86:347-51.

Haapanen A, Ramadan UA, Autti T, Partanen S, Joensuu R, Saftig P, Tyynelä J. In vivo MRI reveals severe atrophy and signal intensity changes in the brains of the cathepsin D knock-out mice. Magn Reson Imaging 2007;25:1024-31.

Kiviharju-af Hällström TM, Jäämaa S, Mönkkönen M, Peltonen K, Andersson LC, Medema RH, Peehl DM, Laiho M. Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement. Proc Natl Acad Sci USA 2007;104:7211-16.

Koivusalo M, Jansen M, Somerharju P, Ikonen E. Endocytic trafficking of sphingomyelin depends on its acyl chain length. Mol Biol Cell 2007;18:5113-23.

Koopal S, Furuhjelm JH, Järviluoma A, Jäämaa S, Pyakurel P, Pussinen C, Wirzenius M, Biberfeld P, Alitalo K, Laiho M, Ojala PM. Viral oncogene-induced DNA damage response is activated in Kaposi’s sarcoma tumorigenesis. PLoS Pathogens 2007;3:1348-60.

Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel M, Segil N, Pirvola U. p19Ink4d and p21Cip1 collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neuroscience 2007;27:1434-44.

Linder MD, Uronen RL, Hölttä-Vuori M, van der Sluijs P, Peränen J, Ikonen E. Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. Mol Biol Cell 2007;18:47-56.

Muranen T, Grönholm M, Lampin A, Lallemand D, Zhao F, Giovannini M, Carpén O. The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton. Hum Mol Genet 2007;16:1742-51.

Nieminen AI, Partanen JI, Hau A, Klefstrom J. c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J 2007;26:1055-67.

Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 2007;104:14694-9.

Poduval P, Sillat T, Beklen A, Kouri VP, Virtanen I, Konttinen YT. Type IV collagen a-chain composition in normal and arthritic synovial lining. Arthritis Rheum 56:3959-67.

Sarek G, Kurki S, Enbäck J, Iotzova G, Haas J, Laakkonen P, Laiho M, Ojala PM. Therapeutic potential of small-molecule inhibitor of the p53-Mdm2 interaction in primary erffusion lymphomas. J Clin Invest 2007;117:1019-28.

Strbian D, Tatlisumak T, Ramadan UA, Lindsberg PJ. Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 2007;27:795-802.

Tammela T, Saaristo A, Holopainen T, Lyytikkä J, Kotronen A, Pitkonen M, Abo-Ramadan U, Ylä-Herttuala S, Petrova TV, Alitalo K. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med 2007;13:1458–66.

Taskinen M, Karjalainen-Lindsberg M-L, Nyman H, Eerola L-M, Leppä S. A high tumor-associated macrophage content predicts favourable outcome in follicular lymphoma patients treated with rituximab and CHOP. Clin Cancer Res 2007;13:5784-89.

Vainionpää N, Bützow R, Hukkanen M, Jackson DG, Pihlajaniemi T, Sakai LY, Virtanen I. Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas. Cell Tissue Res 2007;328:317-28.

Vainionpää N, Lehto VP, Tryggvason K, Virtanen I. Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function. Lab Invest 2007;87:780-91.

Willberg J, Hormia M, Takkunen M, Kikkawa Y, Sekiguchi K, Virtanen I. Lutheran blood group antigen as a receptor for alpha5 laminins in gingival epithelia. J Periodontol 2007;78:1810-8.

2006

Francí C, Takkunen M, Dave N, Alameda F, Gómez S, Rodríguez R, Escrivà M, Montserrat-Sentís B, Baró T, Garrido M, Bonilla F, Virtanen I, García de Herreros A. Expression of Snail protein in tumor-stroma interface. Oncogene 2006; 25:5134-44.

Frösen J, Marjamaa J, Myllärniemi M, Abo-Ramadan U, Tulamo R, Niemelä M, Hernesniem J, Jääskeläinen J. Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical murine saccular aneurysm model. Neurosurgery 2006;58:936-44.

Grönholm M, Muranen T, Toby GG, Utermark T, Hanemann CO, Golemis EA, Carpén O. A functional association between merlin and HEI10, a cell cycle regulator. Oncogene 2006;25:4389-98.

Gürpinar ÖA, Beklen A, Hukkanen M, Cehreli ZC, Onur MA, Konttinen YT. Effects of two multi-step self-etch primer/adhesives on apoptosis in human gingival fibroblasts in vitro. J Biomed Mat Res Part B - Appl Biomat 2006;79:435-40.

Karvonen U, Jänne OA, Palvimo JJ. Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Exp Cell Res 2006;312:3165-83.

Katz S, Hukkanen M, Lounatmaa K, Rousselle P, Tervo T, Virtanen I. Cooperation of isoforms of laminin-332 and tenascin-CL during early adhesion and spreading of immortalized human corneal epithelial cells. Exp Eye Res 2006;83:1412-22.

Ma GF, Liljeström M, Ainola M, Chen T, Tiainen VM, Lappalainen R, Konttinen YT, Salo J: Expression of ADAM9 (meltrin-?) around aseptically loosened total hip replacement implants. Rheumatology 2006;45:808-14.

Marjamaa J, Tulamo R, Abo-Ramadan U, Hakovirta H, Frösen J, Rahkonen O, Niemelä M, Bornstein P, Penttinen R, Kangasniemi M. Mice with a deletion in the first intron of the Col1a1 gene develop dissection and rupture of aorta in the absence of aneurysms: high-resolution magnetic resonance imaging, at 4.7 T, of the aorta and cerebral arteries. Magn Reson Med 2006;55:592-7.

Ruuttila P, Niiranen H, Kellomäki M, Törmälä P, Konttinen YT, Hukkanen M. Characterization of human primary osteoblast response on bioactive glass (BaG13-93)- coated poly-L,DL-lactide (SR-PLA70) surface in vitro. J Biomed Mater Res B Appl Biomater 2006;78:97-104.

Saaristo A, Tammela T, Färkkilä A, Kärkkäinen M, Suominen E, Ylä-Herttuala S, Alitalo A. Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol 2006;169:1080-87.

Takkunen M, Grenman R, Hukkanen M, Korhonen M, García de Herreros A, Virtanen I. Snail-dependent and -independent epithelial-mesenchymal transition in oral squamous carcinoma cells. J Histochem Cytochem 2006;54:1263-75.

Vainio S, Jansen M, Koivusalo M, Róg T, Karttunen M, Vattulainen I, Ikonen E. Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. J Biol Chem 2006;281:348-55.

Vainionpää N, Kikkawa Y, Lounatmaa K, Miner JH, Rousselle P, Virtanen I. Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am J Physiol Cell Physiol 2006;290:C764-75.

Väänänen AJ, Salmenperä P, Hukkanen M, Rauhala P, Kankuri E. Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages. Free Radic Biol Med 2006;41:120-31.

2005

Hasenson S, Määttä M, Rousselle P, Kikkawa Y, Miner JH, Tervo T, Virtanen I. The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin alpha3beta1. Exp Eye Res 2005; 81:415-21.

Hölttä-Vuori M, Alpy F, Tanhuanpää K, Jokitalo E, Mutka AL, Ikonen E. MLN64 is involved in actin-mediated dynamics of late endocytic organelles. Mol Biol Cell 2005;16:3873-86.

Konttinen YT, Ma J, Ruuttila P, Hukkanen M, Santavirta S. Chondrocyte-mediated collagenolysis correlates with cartilage destruction grades in osteoarthritis. Clin Exp Rheumatol 2005;23:19-26.

Konttinen YT, Tensing EK, Laine M, Porola P, Törnwall J, Hukkanen M. Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren's syndrome. J Rheumatol 2005;32:1071-5.

Ma GF, Ainola M, Liljeström M, Santavirta S, Poduval P, Zhao D, Chen T, Konttinen YT. Increased expression and processing of ADAM 12 (meltrin-a) in osteolysis associated with aseptic loosening of total hip replacement implants. J Rheumatol 32:1943-50, 2005.

Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT. Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation. J Biomed Mater Res B Appl Biomater 2005;74:582-8.

Muranen T, Grönholm M, Renkema GH, Carpén O. Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin. Oncogene 2005;24:1150-8.

Peltonen K, Kiviharju T, Järvinen P, Ra R, Laiho M. Histone deacetylase inhibitor provokes p53 independent cell cycle arrest and apoptosis in melanoma cell lines. Pigment Cell Res 2005;18:196-202.

Rigamonti E, Helin L, Lestavel S, Mutka A-L, Lepore M, Fontaine C, Bouhlel MA, Bultel S, Fruchart JC, Ikonen E, Clavey V, Staels B, and Chinetti-Gbaguidi G. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res 2005;97: 682-689.

2004

Bäck N, Litonius E, Mains RE, Eipper BA. Fluoride causes reversible dispersal of Golgi cisternae and matrix in neuroendocrine cells. Eur J Cell Biol 2004;83:389-402.

Kurki S, Peltonen K, Latonen L, Kiviharju T, Ojala PM, Meek D. Laiho M. Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 2004;5:465-75.

Laine M, Virtanen I, Salo T, Konttinen YT. Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 2004;50:3968-73.

Tatlisumak T, Strbian D, Abo-Ramadan U, Li F. The role of diffusion- and perfusion-weighted magnetic resonance imaging in drug development for ischemic stroke: from laboratory to clinics. Curr Vasc Pharmacol 2004;2:343-55.

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