Translational Cancer Biology Research Program TCB Program Alma-intranet Flammaintra

Translational Cancer Biology Symposium

Welcome to the Translational Cancer Biology Symposium of the Centre of Excellence in Translational Cancer Biology and Translational Cancer Biology Research Program in Helsinki, Finland.

Symosium will be at the Biomedicum Helsinki 1 in the Lecture Hall 1 from 9:00 to 17:15. The symposium is open and free of charge for all the students and researchers of the field. Registration is required and includes lunch and coffees. Please notice the changed timetable of the Session I.

Please register to the Symposium:
Please notice the changed timetable of the Session I.

Translational Cancer Biology Symposium

9:00 Opening words by Dr. Kari Alitalo

Session I: Gastrointestinal Cancer, Chair: Kari Alitalo

9:05-9:35 Calvin Kuo, Stanford University, USA
  Organoids for cancer modeling and oncogene discovery
9:35-10:05 Livio Trusolino, University of Turin, Italy
  Putting drivers and targets in context: Lessons from colorectal cancer patient-derived tumor grafts

10:05 Coffee break

10:30-11:00 Robert Vries, Foundation Hubrecht Organoid Technology, The Netherlands
  Organoids, a disease and patient specific in vitro model system
11:00-11:15 Carina Holmberg, University of Helsinki, Finland
  UCHL5 as a potential prognostic marker in colorectal cancer
11:15-11:45 David Tuveson, Cold Spring Harbor Laboratory, USA
  Redox regulation in pancreatic cancer

11:45 Poster session with lunch and coffee

Session II: Microenvironment, Chair: Tomi Mäkelä

13:30-14:00 Jeffrey W. Pollard, University of Edinburgh, UK
  Tumor associated macrophages: From mechanism to therapy
14:00-14:20 Johanna Ivaska, University of Turku, Finland
  Tumor stroma crosstalk regulates carcinoma cell proliferation
14:20-14:35 Pipsa Saharinen, University of Helsinki, Finland
  Regulation of endothelial barrier by Angiopoietin-2 in tumorigenesis and inflammation
14:35-14:50 Päivi Ojala, University of Helsinki, Finland
  Modeling molecular crosstalk of tumor cells and lymphatic endothelium in melanoma metastasis

14:50 Coffee break

Session III: Mechanisms, Chair: Johanna Ivaska

15:20-15:50 Christophe Lamaze, Institut Curie, France
  Mechanosensing and mechanotransduction in breast cancer: Role of caveolae
15:50-16:05 Juha Klefström, University of Helsinki, Finland
  Mechanisms of epithelial integrity loss in cancer
16:05-16:20 Pirjo Laakkonen, University of Helsinki, Finland
  Metabolic changes that affect glioma survival

Session IV: Immune therapy, Chair: Johanna Ivaska

16:20-16:50 Karin De Visser, Netherlands Cancer Institute, The Netherlands
  Cancer-initiated systemic inflammation facilitates breast cancer metastasis
16:50-17:15 Sirpa Jalkanen, University of Turku, Finland

New players in lymphatics: Any role in cell trafficking?


Pre-Symposium Workshop for students will be on August 26, 2015.

Students can receive credits for confirmed participation on Pre-Symposium Workshop, Symposiun, and for presenting a poster.



If you wish to submit a poster to the poster session, please send your poster's abstract to Dr. Michael Jeltsch ( by August 23, 2015.

For more information please contact Kaisa Sarkkinen (