M.D., Ph.D., Professor
Translational Cancer Biology Research Program Haartman Institute Biomedicum Helsinki
P.O. Box 63 (Haartmaninkatu 8) FI-00014 University of Helsinki Finland
Tel. +358 2 941 25566 Fax +358 2 941 25610
Secretary Merja Koivulahti
- Translational Cancer Biology Research Program
- Haartman Institute
- Helsinki Biomedical Graduate Program
- Helsinki Graduate Program in Biotechnology and Molecular Biology
Transforming Growth Factor Beta in Cancer
Interplay mechanism between NTN4 and ITGB4 during glioma progression. At the initial stage of glioma progression, NTN4 concentration stays relatively high in extracellular environment. High concentrations of NTN4 have an ability to reduce cell proliferation through UNC5B. During progression, glioma cells reduce NTN4 expression to prevent the negative effects on glioma cell growth induced by NTN4. In parallel, ITGB4 expression increases. In this way, excessive ITGB4 makes glioblastoma cells hyperresponsive to low concentrations of NTN4 for keeping AKT/mTOR phosphorylation and glioma cell proliferation.
Hu, Y., Ylivinkka, I., Chen, P., Li, L., Hautaniemi, S., Nyman, TA., Keski-Oja, J. and Hyytiäinen, M.* (2012) Netrin-4 promotes glioblastoma cell proliferation through integrin beta4 signalling. Neoplasia 14(3):219-227.