Selected Publications

Loukovaara S, Lehti K, Robciuc A, Pessi T, Holopainen JM, Koli K, Immonen IR and Keski-Oja J: Increased intravitreal angiopoietin -2 levels associated with rhegmatogenous retinal detachment. Submitted to Graefes Arch Clin Exp Ophthalmol, in press 2013.

Li L, Hu Y, Ylivinkka I, Li H, Keski-Oja J and Hyytiäinen M: Netrin-4 protects glioblastoma cells from temozolomide induced cell senescence. PLoS One, in press, 2013.

Makarov A, Nyman TA, Ylivinkka I, Hyytiäinen M, and Keski-Oja J: Ephrin-As, Eph receptors and integrin alpha-3 interact and colocalize at membrane protrusions of U251MG glioblastoma cells. Cell Biol. Int. 37: 1080-1088, 2013.

Ylivinkka I, Hu Y, Chen P, Hautaniemi S, Rantanen V, Nyman TA, Keski-Oja J and Hyytiäinen M: Netrin-1 induced activation of Notch signaling mediates glioblastoma cell invasion. J. Cell Sci. 126: 2459-2469, 2013.

Loukovaara S, Robciuc A, Holopainen JM, Lehti K, Pessi T, Liinamaa J, Kukkonen KT, Jauhiainen M, Koli K, Keski-Oja J and Immonen I: Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGF-beta-1 in diabetic eyes undergoing vitrectomy. Acta Ophthalmol. 91: 531-539, 2013.

Chen H, KO MJ, Wong VC, Hyytiäinen M, Keski-Oja J, Chua D, Nicholls JM, Cheung FM, Lee AW, Kwong DL, Chiu PM, Zabarovsky ER, Tsao SW, Tao Q, Chan SH, Stanbridge EJ and Lung ML: LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. Cancer Letters, 325: 89-98, 2012.

Leppäranta O, Sens C, Salmenkivi K, Kinnula VL, Keski-Oja J, Myllärniemi M and Koli K: Regulation of TGF-beta storage and activation in the human idiopathic pulmonary fibrosis lung. Cell Tissue Res. 348: 491-503, 2012.

Hu Y, Ylivinkka I, Chen P, Li L, Hautaniemi S, Keski-Oja J and Hyytiäinen M: Netrin-4 promotes glioblastoma cell proliferation via integrin beta-4 signaling. Neoplasia 14: 219-227, 2012.

Tamminen JA, Myllärniemi M, Hyytiäinen M, Keski-Oja J and Koli K: Asbestos exposure induces alveolar epithelial cell plasticity. J. Cell. Biochem. 113: 2234-2247, 2012.

Tatti O, Arjama M, Ranki A, Weiss SJ, Keski-Oja J and Lehti K: Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion. PLoS ONE, 6 (12): e28325 (13 pp.), 2011.

Chan SH, Yee Ko JM, Chan KW, Chan YP, Tao Q, Hyytiäinen M, Keski-Oja J, Law S, Srivastava G, Tang J, Tsao SW, Chen H, Stanbridge EJ and Lung ML: The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome. Int. J. Cancer 129: 565-573, 2011.

Vehviläinen P, Koli K, Myllärniemi M, Lindholm P, Soini Y, Salmenkivi K, Kinnula VL and Keski-Oja J: Latent TGF-beta binding proteins (LTBPs) -1 and -3 differentially regulate TGF-beta activity in malignant mesothelioma. Hum. Pathol. 42: 269-78, 2011.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, and Lehti K: FGF receptor-4 (FGFR4 ) polymorphism acts as an activity switch of a membrane-type-1 matrix metalloproteinase-FGFR4 complex. Proc. Natl. Acad. Sci. U.S.A. 107:15786-15791, 2010.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J and Lehti K: Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. Cancer Res. 70: 7851-7861, 2010.

Kantola AK, Ryynänen MJ, Lhota F, Keski-Oja J and Koli K: Independent regulation of short and long forms of latent TGF-b binding protein (LTBP)-4 in cultured fibroblasts and human tissues. J. Cell. Physiol. 223: 727-736, 2010.

Wempe F, De-Zolt S, Koli K, Bangsow T, Parajuli N, Dumitrascu R, Sterner-Kock A, Weissmann N, Keski-Oja J and von Melchner H: Inactivation of sestrin 2 induces TGF-b signaling and partially rescues pulmonary emphysema in a mouse model of COPD. Dis. Model Mech. 3: 246-253, 2010.

Vehviläinen P, Hyytiäinen M and Keski-Oja J: Matrix association of latent TGF-b binding protein-2 (LTBP-2) is dependent on fibrillin-1. J. Cell Physiol. 221: 586-593, 2009.

Leppäranta O, Myllärniemi M, Salmenkivi K, Kinnula VL, Keski-Oja J and Koli K: Reduced phosphorylation of the TGF-b signal transducer Smad2 in emphysematous human lung. COPD (J. Chron. Obstr. Pulm. Dis.) 6: 234-241, 2009.

Tritschler I, Gramatzki D, Capper D, Mittelbronn M, Saharinen J, Wick W, Keski-Oja J and Weller M: Modulation of TGF-b activation by latent TGF-b-binding protein 1 in human malignant glioma cells. Int. J. Cancer 125: 530-540, 2009.

Full list of publications