Contact Information:
Marikki Laiho
M.D., Ph.D., Professor
Molecular Cancer Biology Program
Biomedicum Helsinki
Haartman Institute,
PO BOX 63 (Haartmaninkatu 3)
FI-00014 University of Helsinki
Finland
Tel: +358-9-1912 5540
Fax: +358-9-1912 5554
E-mail: firstname.surname@helsinki.fi
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Selected publications
- Buzek J, Latonen L, Kurki S, Laiho M. Redox state of tumor suppressor p53 regulates its sequence specific DNA binding in DNA-damaged cells by cysteine 277. Nucl Acids Res 30: 2340-2348 , 2002.
- Zhang F, Lundin M, Ristimäki A, Heikkilä P, Lundin J, Isola J, Joensuu H, Laiho M. Ski-related novel protein N (SnoN), a negative controller of TGF-ß signaling, is a prognostic marker in ER-positive breast carcinomas. Cancer Res 63: 5005-5010, 2003.
- Gentile M, Latonen L, Laiho M. Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses. Nucl Acids Res 31: 4779-4790, 2003.
- Kurki S, Latonen L, Laiho M. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J Cell Sci 116: 3917-3925, 2003.
- Kurki S, Peltonen K, Latonen L, Kiviharju T, Ojala PM, Meek D Laiho M. Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 5: 465-475, 2004.
- Willebrand M, Köhler K, Alanko T, Laiho M, Saksela O. FGF-2 prevents
decrease in Bcl-2 level and apoptosis induced by TGF-ß1 in normal
melanocytes but not in nevus or melanoma cells. Exp Dermatology 14: 202-208,
2005.
- Peltonen K, Kiviharju T, Järvinen P, Ra R, Laiho M. Histone deacetylase
inhibitor provokes p53 independent cell cycle arrest and apoptosis in
melanoma cell lines. Pigment Cell Res 18: 196-202, 2005.
- Latonen L, Laiho M. Cellular UV damage responses - functions of tumor
suppressor p53. BBA Reviews in Cancer 1755: 71-89, 2005.
Page updated
December 20, 2006
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