ALL PUBLICATIONS

PUBLICATIONS IN REVIEWED JOURNALS:
1. Klefstrom, J., Koskinen, P., Saksela, E., Jäättelä, M., Bravo, R., Alitalo, K.: A subset of immediate early mRNAs induced by tumor necrosis factor-a during cellular cytotoxic and non-cytotoxic responses. Int J Cancer 55: 655-659, 1993
2. Knuutila, S., Klefstrom, J., Szymanska, J., Lakkala, T., Peltomäki, P., Eray, M., Teerenhovi, L., Elonen, E., Franssila, K.O.,  Kaartinen, M.: Two novel human non-Hodgkin´s lymphoma derived B-cell lines: Cytogenetic, molecular genetic and cell immunophenotype analyses. Eur J Hematol 52: 65-72, 1994
3. Klefstrom, J., Franssila, K., Peltomäki, P., Kaartinen, M., Solin, M. L., Knuutila, S.: Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin´s lymphomas. Leukemia Res 18: 245-250, 1994
4. Klefstrom, J., Västrik, I., Saksela, E., Valle, J., Eilers, M., Alitalo, K.: c-Myc induces cellular susceptibility to the cytotoxic action of TNF-a EMBO J 13, 5442-5450, 1994.
IF (05): 10.05, Cited (05/07): 108
5. Enholm, B., Paavonen, K., Ristimaki, A., Kumar, V., Klefstrom, J., Kivinen, L., Laiho, M., Olofsson, B., Joukov, V., Eriksson, U. and Alitalo, K: Regulation of VEGF-B and VEGF-C mRNAs by serum, growth factors and oncoproteins. Oncogene14, 2475-2483, 1997.
IF (05): 6.87, Cited (05/07): 238
6. Monni, O., Joensuu, H., Franssila, K., Klefstrom, J., Alitalo, K., and Knuutila, S.: BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 90, 1168-1174, 1997. IF (05): 10.13, Cited (05/07): 92
7. Klefstrom*, J., Arighi*, E., Littlewood, T., Jäättelä, M., Saksela, E., Evan, G., and Alitalo, K.: Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kB activation. EMBO J 16, 7382-7392, 1997.
IF (05): 10.05, Cited (05/07): 76
8. Kinnula V.L., Aito, H., Klefstrom, J., Alitalo, K., and Raivio, K.O.: Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro. Cancer Lett 125, 191-198, 1998.
IF (05): 3.05, Cited (05/07): 5
9. Klefstrom, J.,  Kovanen, P.,  Somersalo, K., Littlewood, T., Evan, G., Saksela, E., Timonen, T., and Alitalo, K.: c-Myc and E1A promote target cell cytolysis by natural killer cells by acting after the exocytotic phase. Oncogene 18, 2181-2188, 1999
IF (05): 6.87, Cited (05/07): 9
10. Klefstrom J, Verschuren EW, Evan G. c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. J Biol Chem. 277, 43224-43232, 2002.
IF (06): 5.81, Cited (05/07): 23
11. Verschuren EW, Klefstrom J, Evan GI, Jones N. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.
Cancer Cell. 2, 229-241, 2002. IF (06): 24.08, Cited (05/07): 40
12. Nieminen A, Partanen J, Hau A, Klefstrom J: c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J, 26, 1444-1455, 2007.
IF (06): 10.09, Cited (05/07): N/A
13. Partanen J, Nieminen A, Makela T, Klefstrom J: Suppression of oncogenic properties of c-Myc by Lkb1 controlled epithelial organization, PNAS, 104, 14694-14699, 2007. IF (06): 9.64, Cited (05/09): 8
14. Nieminen H1, Nieminen A2, Saarela M3,Kallioniemi A4, Klefström J2, Hautaniemi S5, Monni, O*1: Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer. BMC Genomics, 9, 348, 2008 IF (06): 4.03, Cited (05/09): 2
15. Rajecki M, af Hallstrom T, Hakkarainen T, Nokisalmi P, Hautaniempi S, Nieminen, AI, Tenhunen M, Rantanen V, Desmond R, Chen DT, Guse K, Stenman UH, Gargini R, Kapanen M, Klefstrom J, Kanerva A, Pesonen S, Ahtiainen L, Hemminki A: Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. Int J Cancer, in press. IF (06): 4.69, Cited (05/09): N/A

BOOKS AND REVIEWS:
16.Klefstrom J., Saksela, E., and Alitalo, K.: Molecular mechanisms controlling susceptibility to Tumor Necrosis Factor induced cell death. In Book: Tsiftsoglou AS (eds) Regulation of cell growth, differentiation and genetics in cancer. Springer-Verlag Heidelberg (1996) p.143-154
17. Klefström, J., Kaartinen, M., Peltomäki, P., Solin, M. L., Franssila, K., Knuutila, S.: Polymeraasiketjureaktion (PCR) käyttö non-Hodgkin lymfoomien diagnostiikassa. Duodecim 106: 1645-1653, 1990 (in Finnish)
18.Klefström, J., Saksela, E., Alitalo, K.: Tuumorinekroosifaktori ja solutapon monimutkainen laukaisumekanismi. Duodecim 108:1449-1455, 1992 (in Finnish)
19.Västrik, I., Mäkelä, T.P., Koskinen, P.J., Klefstrom, J., Alitalo, K.: Myc protein, partners and antagonists. Crit Rev Oncogen 5:59-68, 1994
20. Klefström, J., Alitalo, K.: Lentivirukset hyötykäyttoon. Duodecim (pääkirjoitus/editorial) 119, 1917-1919, 2003
21. Nieminen AI, Partanen JI, Klefstrom J.: c-Myc blazing a Trail of death: Coupling of the mitochondrial and death receptor pathways by c-Myc. Cell Cycle (invited review), 6:2464-2472, 2007. IF (06): 3.21, Cited (05/09): 11
22. Partanen JI, Klefström, J: Soluviljelyn uudet ulottuvuudet - muovilta matriksiin. Duodecim (katsaus), 124:2444-2451, 2008.
23. Partanen JI, Nieminen A, Klefström, J: 3D view to tumor suppression: Lkb1, epithelial organization, and the arrest of oncogenic c-Myc. Cell Cycle (invited review), 8:716-724, 2009. IF (06): 3.21, Cited (05/09): N/A

OTHER PUBLICATIONS:
24. Klefstrom J.: Oncogenes as Regulators of Tumor Necrosis Factor Induced Cell Death. Thesis, 1997