Contact information

Outi Monni, Ph.D., Academy Research Fellow

Genome-Scale Biology Research Program,
Institute of Biomedicine,
Biomedicum Helsinki,
POBox 63
(Haartmaninkatu 8)
00014 University of Helsinki
FINLAND  
+358 40 7639302
Email: firstname.surname @helsinki.fi


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Research at the Oncogenomics lab

Monni lab

My group is interested in finding putative oncogenic drivers and drug targets in specific epithelial cancers. Particularly, we focus on those genes that are deregulated due to genetic alteration and therefore, may reflect alterations causally contributing to tumorigenesis or progression. Previously, we have performed systematic genomic and transcriptomic profiling of multiple cancer cell lines and tumor samples to identify putative oncogenes and tumor suppressors whose expression is associated with underlined genetic alterations. Especially, high-level amplifications have a clear impact on gene expression and these alterations are also associated with poor prognosis.

Our interest is to dissect the role of the genes mapping to these amplicons, particularly 11q13, which is one of the most commonly amplified regions in several epithelial cancers. Recently, we have studied the role of two genes, PPFIA1 and ANO1, encoding liprin-α1 and anoctamin 1, and found mechanistic insights how they contribute to cancer progression, cellular adhesion and invasion in carcinoma cell lines. We are also interested in finding novel biomarkers for sensitivity and resistance to cancer therapeutics by correlating the drug response to genetic determinants. Currently, our main focus is in squamous cell carcinoma of head and neck and breast cancer.