Publications

PhD theses:

• Liisa Myllykangas: Genetic modulation of of age-associated brain pathology. University of Helsinki , Faculty of Medicine, 2002. Supervisors: Matti Haltia and Pentti Tienari.
• Marja-Liisa Sumelahti: Occurrence and Natural Course of Multiple Sclerosis in Finland University of Tampere , Faculty of Medicine, 2002. Supervisors: Matti Hakama, Juhani Wikström, Pentti Tienari.

Original articles on multiple sclerosis

• Riise Stensland HMF, Saarela J, Bronnikov DO, Parkkonen M, Jokiaho AJ, Palotie A, Tienari PJ, Sumelahti M-L, Elovaara I, Koivisto K, Pirttilä T, Reunanen M, Sobel E, Peltonen L (2005) Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12. J Neuroimmunol 170(1-2):122-33
• Lincoln MR, Montpetit A, Cader MZ, Saarela J, Dyment DA, Tiislar M, Ferretti V, Tienari PJ, Peltonen L, Ebers GC, Hudson TJ (2005) A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis . Nature Genet 37(10):1108-12.
• Riise Stensland HMF, Saarela J, Bronnikov DO, Parkkonen M, Jokiaho AJ, Palotie A, Tienari PJ , Sumelahti M-L, Elovaara I, Koivisto K , Pirttilä T , Reunanen M , Sobel E, Peltonen L (2005) Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12. J Neuroimmunol (in press)
• Tienari PJ, Sumelahti M-L, Rantamäki-Häkkinen T, Wikström J (2004) Multiple sclerosis in western Finland : Evidence for founder effect. Clin Neurol Neurosurg 106, 175-179.
• Bonetti A, Reunanen K, Finnilä S, Koivisto K, Wikström J, Sumelahti M-L, Pirttilä T, Elovaara I, Reunanen M, Peltonen L, Rantamäki T, Tienari PJ (2004) A two-stage study on multiple sclerosis and chromosome 2q33. Genes Imm 5, 142-146.
• Sumelahti ML, Tienari PJ, Hakama M, Wikström J. (2003) MS in Finland : trends and differences in relapsing remitting and primary progressive disease- courses . J Neurol Neurosurg Psychiatry 74, 25-28.
• Pihlaja, H, Rantamäki-Häkkinen T, Wikström J, Sumelahti M-L, Pirttilä T, Elovaara, I, Reunanen M, Ilonen J, Ruutiainen J, Kuokkanen S, Peltonen L, Koivisto K, Tienari PJ. (2003) Linkage disequilibrium between myelin basic protein (MBP) microsatellite and multiple sclerosis is restricted to a geographically-defined subpopulation in Finland . Genes & Immunity 4, 138-146.
• Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J Wikström J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J (2003) Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol 64, 345-9 .
• Laaksonen M, Pastinen T, Sjöroos M, Kuokkanen S, Ruutiainen J, Sumelahti M-L, Reijonen H, Salonen R, Wikström J, Panelius M, Partanen J, Tienari PJ, Ilonen J (2002) HLA class II associated risk and protection against multiple sclerosis - a Finnish family study. J Neuroimmunol 122, 140-145.
• Sumelahti ML, Tienari PJ, Wikström J, Palo J, Salminen T, Hakama M. (2002) Survival of multiple sclerosis in Finland during 1979-93. Mult Scler 8, 350-355.
• Reunanen K, Finnilä S, Laaksonen M, Sumelahti M-L, Wikström J, Pastinen T, Kuokkanen S, Saarela J, Uimari P, Ruutiainen J, Ilonen J, Peltonen L, Tienari PJ (2002) Chromosome 19q13 and multiple sclerosis susceptibility in Finland: Linkage and two-stage association study. J Neuroimmunol 126,134-42.

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• Saarela J, Schoenberg Fejzo M, Chen, D, Finnilä S, Parkkonen M, Kuokkanen S, Sobel E, Tienari PJ, Sumelahti M-L, Wikström J, Elovaara I, Koivisto K, Pirttilä T, Reunanen M, Palotie A, Peltonen L. Fine mapping of multiple sclerosis locus on chromosome 17q22-q24. Hum Mol Genet 11, 2257-2267.
• Sumelahti ML, Tienari PJ, Palo Jorma, Wikström J, Hakama M. Increasing prevalence of multiple sclerosis in Finland (2001) Acta Neurol Scand 103, 153-158.
• Sumelahti ML, Tienari PJ, Wikström J, Palo J, Hakama M. Regional and temporal variation in multiple sclerosis incidence in Finland during 1979-93 (2000) Neuroepidemiology 19, 67-75.
• Lindqvist AK , Allen M, Lähdetie J, Tienari PJ, Wikström J, Palo J, , Peltonen L, Gyllensten U. Contribution of the HLA class II genes DPB1, DRB1, DQA1 and DQB1 to multiple sclerosis: a combined effect of DQ and DR loci? (2000) Hereditas 132, 89-94.
• Tienari PJ, Reunanen K (1999) Chromosome 19 locus Apolipoprotein CII association with multiple sclerosis (letter). Mult Scler 5, 378.
• Tienari PJ, Kuokkanen S, Pastinen T, Wikström J, Sajantila A, Sandberg-Wollheim M, Palo J, Peltonen L. (1998) Golli-MBP gene in multiple sclerosis susceptibility. J Neuroimmunol 81, 158-167.
• Wansen K, Pastinen T, Kuokkanen S, Wikström J, Palo J, Peltonen L, Tienari PJ (1997) Immune system genes in multiple sclerosis: Association and linkage analyses on TCR b , IGH, IFN- g and IL-1ra/IL-1 b loci . J Neuroimmunol 79, 29-36.
• Kuokkanen S., Gschwend M, Daly MJ, Terwilliger JD, Tienari PJ , Wikström J, Palo J, Stein L, Hudson T, Lander E, Peltonen L (1997) Genome-wide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet 61, 1379-1387.
• Kuokkanen S, Sundvall M, Terwilliger JD, Tienari PJ, Wikström J, Holmdahl R, Petterson U, Peltonen L (1996) A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to eae2. Nature Genet 13, 477-480 .
• Tienari PJ, Terwilliger JD, Ott J, Palo J, Peltonen L (1994) Two-locus linkage analysis in multiple sclerosis (MS). Genomics 19, 320-325 .
• Tienari PJ, Wikström J, Koskimies S, Partanen J, Palo J, Peltonen L (1993) Reappraisal of HLA in multiple sclerosis: close linkage in multiplex families. Eur J Hum Genet 1, 257-268.
• Tienari PJ, Salonen O, Wikström J, Valanne L, Palo J (1992) Familial multiple sclerosis: MRI findings in clinically affected and unaffected siblings. J Neurol Neurosurg Psychiatry 55, 883-886.
• Tienari PJ, Wikström J, Sajantila A, Palo J, Peltonen L (1992) Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene. Lancet 340, 987-991 .

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Original articles on neurodegeneration

• Scholz S, Xiromerisiou G, Fung HC, Eerola J, Hellström O, Papadimitriou A,
  Hadjigeorgiou GM,  Tienari PJ,  Fernandez HH, Mandel R, Okun MS, Gwinn-Hardy
  K, Singleton A (2005) The human prion gene M129V polymorphism is not
  associated with idiopathic Parkinson's disease in three distinct
  populations. Neurosci Lett. 2005 Nov 17; [Epub ahead of print]
• Linnankivi T, Tienari P, Somer M, Kähkönen M, Lönnqvist T, Valanne L, Pihko
  H. 18q deletions: clinical, molecular and brain MRI findings of 14
  individuals. Am J Med Genet (in press).
• Tanskanen M, Lindsberg PJ, Tienari PJ, Polvikoski T, Sulkava R, Verkkoniemi
  A, Rastas-Luukkonen S, Paetau A, Kiuru-Enari S (2005) Cerebral amyloid
  angiopathy in a 95+ cohort: complement activation and ApoE genotype.
  Neuropathol Appl Neurobiol 31(6):589-99.
• Clarimon J, Johanna Eerola, Hellström O, Peuralinna T, Tienari PJ, Singleton AB (2005) Assessment of PINK1 (PARK6) polymorphisms in Finnish PD . Neurobiol Aging 2005 Jul 18; [Epub ahead of print].
• Clarimon J , Xiromerisiou G , Eerola J , Gourbali V , Hellstrom O , Dardiotis E , Peuralinna T , Papadimitriou A , Hadjigeorgiou GM , Tienari PJ , Singleton AB . (2005) Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients. BMC Neurol Jun 20;5:11.
• Eerola J, Tienari PJ, Kaakkola S, Nikkinen P, Launes J (2005) How useful is [ 123 I ]b -CIT SPECT in clinical practise? J Neurol Neurosurg Psychiatry 76(9):1211-1216.
• Paisán-Ru ? z C, Evans EW, Jain S, Xiromerissiou G, Gibbs JR, Eerola J, Gourbali V, Aggelakis 2 , Hellström O, Scarmeas N, Papadimitriou S, Tienari PJ, Hadjigeorgiou GM, Singleton AB (2005) LRRK2 , the gene underlying PARK8 Parkinson's disease; testing association in sporadic Parkinson's disease and patterns of linkage disequilibrium in diverse ethnic groups. J Med Genet (in press)
• Myllykangas L, Wavrant-DeVrièze F, Polvikoski T, Notkola I-L, Sulkava R, Niinistö L, Edland S , Arepalli S, Adighibe O, Compton D , Hardy J, Haltia M, Tienari PJ. (2005) Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: A two-stage study. J Neurol Sci 236:17-24.
• Greggio E, Bergantino E, Carter D, Ahmad R, Costin G-E, Hearing VJ, Clarimon J, Singleton A, Eerola J, Hellström O, Tienari PJ, Miller DW, Beilina A, Bubacco L, Cookson MR (2005) Tyrosinase exacerbates dopamine and a -synuclein toxicity but is not genetically associated with Parkinson's disease. J Neurochem 93(1):246-256.
• Strandberg TE, Pitkälä K, Eerola J, Tilvis R, Tienari PJ (2005) Interaction of herpesviridae, APOE gene, and education in cognitive impairment. Neurobiol Aging 26(7):1001-1004.
• Buervenich S, Carmine A, Galter D, Shahabi HN, Johnels B, Holmberg B, Ahlberg J, Nissbrandt H, Eerola J, Hellström O, Tienari PJ, Matsuura T, Ashizawa A, Wüllner U, Klockgether T, Zimprich A, Gasser T, Hanson M, Singleton A, McMahon FJ, Anvret M, Sydow O, Olson LA (2005) Rare Truncating Mutation in ADH1C (G78stop) Shows Significant Association with Parkinson's Disease in a Large International Sample. Arch Neurol 62(1):74-78.
• Evans W, Fung HC, Steele J, Eerola J, Tienari P, Myers A, Wavrant DeVrieze F, Singleton A, Hardy J (2004) Tau H2 haplotype is almost exclusively Caucasian in origin. Neurosci Lett 369:183-185.
• Clarimon J, Eerola J, Hellström O, PJ Tienari, Singleton A (2004) Paraoxonase 1 ( pon1 ) gene polymorphisms and parkinson's disease in a Finnish population. Neurosci Lett 367:168-170.
• Johnson J, Hague SM, Hanson M, Gibson A, Wilson KE, Singleton AA, McInerney-Leo A, Nussbaum RL, Hernandez DG, Gallardo M, McKeith IG, Burn DJ, Ryu M, Ravina B, Perry RH, Jaros E, Eerola J, Tienari PJ, Hellström O, Weiser R, Gwinn-Hardy K, Morris CM, Hardy J and Singleton AB (2004) SNCA multiplication is not a common cause of Parkinson's disease or dementia with Lewy bodies. Neurology 63, 554-556.
• Hague S, Peuralinna T, Eerola J, Hellström O, Tienari PJ, Singleton AB (2004) Confirmation of the protective effect of the iNOS gene in an independent European cohort of Parkinson's disease. Neurology 62, 635-637 .
• Linnankivi TT, Autti TH, Pihko SH, Somer MS, Tienari PJ, Wirtavuori KO, Valanne LK (2003) 18q- Syndrome: Brain MRI shows poor differentiation of gray and white matter on T2-weighted images. J Magn Reson Imaging 18, 414-419
• Eerola J, Hernandez D, J. Launes J, Hellström O, Hague S, Gulick C, Johnson J, Hardy J, Tienari PJ, Singleton AB (2003) Assessment of a DJ-1 (PARK7) polymorphism in Finnish Parkinson's disease. Neurology 61, 1000-1002.
• Nissinen R, Paimela L, Julkunen H, Tienari PJ, Leirisalo-Repo M, Palosuo T, Vaarala O (2003) Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren syndrome. Scand J Rheumatol 32, 337-342.
• Myllykangas L, Polvikoski T, Reunanen K, Wavrant-De Vrieze F, Ellis C, Hernandez D, Sulkava R, Kontula K, Verkkoniemi A, Notkola I-L, Hardy J, Perez-Tur J, Haltia MJ, Tienari PJ (2002) ApoE e 3-haplotype modulates Alzheimer's amyloid-beta deposition in the brain. Am J Med Genet 114, 288-291

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• Lambert J-C, Goumidi L, Myllykangas L, Ellis C, Wang JC, Bullido MJ, Harris JM, Artiga MJ, Hernandez D, Kwon JM, Frigard B, Peterson RC, Cummings A, Pasquier F, Polvikoski T, Sastre I, Tienari PJ, Frank A, Sulkava R, Morris JC, St Clair D, Mann DM, Amouyel P, Hardy J, Valdivieso F, Goate AM, Haltia M, Pérez-Tur J, Lendon CL, Chartier-Harlin M-C (2002) Contribution of APOE promoter polymorphisms to Alzheimer's disease risk . Neurology 59, 59-66.
• Eerola J, Hellström O, Launes J, Tienari PJ. (2002) Analysis of ApoE, Parkin and COMT genes in sporadic Parkinson's disease in Finland . Neurosci Lett 330, 296-299.
• Myllykangas, L, Polvikoski T, Sulkava R, Notkola I-L, Rastas S, Verkkoniemi A, Tienari PJ, Niinistö L, Hardy J, Perez-Tur J, Kontula K, Haltia M (2001) Genetic Association of Lipoprotein Lipase Variant Ser447Ter with Brain Infarction. Ann Med 33, 486-492.
• Baker M, Graff-Radford D, Wavrant DeVrièze F, Graff-Radford N, Petersen RC, Kokmen E, Boeve B, Myllykangas L, Polvikoski T, Sulkava R, Verkoniemi A, Tienari P, Haltia M, Hardy J, Hutton M, Perez-Tur J (2000) No Association between Tau Haplotype and Alzheimer's Disease in Population or Clinic Based Series or in Familial Disease. Neurosci Lett 285, 147-149.
• Myllykangas L, T. Polvikoski, R. Sulkava, A. Verkkoniemi, P. Tienari, L. Niinisto, K. Kontula, J. Hardy, M. Haltia, J. Perez-Tur (2000) Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over. Neurosci Lett 292, 195-198 .
• Autti T, Muttilainen M, Raininko R, Heiskala H, Puranen J, Häkkinen A-M, Tienari P, Santavuori P, Suominen P, Somer M. (1999) Extensive cerebral white matter abnormality without clinical symptoms: A new hereditary condition? Ann Neurol 45, 801-805.
• Myllykangas L, Polvikoski T, Sulkava R, Verkkoniemi A, Crook R, Tienari P, Pusa A-K, Niinistö L, O'Brien P, Kontula KM, Hardy J, Haltia M, Pérez-Tur J (1999) Alpha 2-macroglobulin: Genetic association with Alzheimer's disease in a Finnish elderly population. Ann Neurol 46, 382-90.
• Tienari PJ, Ida N, Ikonen E, Simons M, Multhaup G, Weidemann A, Masters CL, Dotti CG, Beyreuther K (1997) Intracellular and secreted Alzheimer´s b -amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. Proc Natl Acad Sci USA 94, 4125-4130
• Hartmann T, Bieger SC, Bruehl B, Tienari PJ, Ida N, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K. (1997) Identification of cellular compartments of Alzheimer's disease b -amyloid peptide generation. Nature Med 3, 1016-1020.
• Hartmann T, Bergsdorf C, Sandbrink R, Tienari PJ, Multhaup G, Ida N, Bieger S, Dyrks T, Weidemann A, Masters CL, Beyreuther K (1996). Alzheimer´s disease beta A4 protein release and amyloid precursor protein sorting are regulated by alternative splicing. J Biol Chem 271, 13208-13214.
• Simons M, De Strooper B, Multhaup G, Tienari PJ, Dotti CG, Beyreuther K (1996) Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. J Neurosci 16, 899-908 .
• Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG (1996) The b -amyloid domain is essential for axonal sorting of amyloid precursor protein. EMBO J 15, 5218-5229.
• Simons M, Ikonen E, Tienari PJ, Cid-Arregui A, Mönning U, Beyreuther K, Dotti CG (1995) Intracellular routing of human amyloid precursor protein: Axonal delivery followed by transport to the dendrites. J Neurosci Res 41, 121-128 .
• Simons M, Tienari PJ, Dotti CG, Beyreuther K (1995) Two-dimensional gel mapping of the processing of the human amyloid precursor protein in rat hippocampal neurons. Febs Lett 368, 363-366.
• Czech C, Mönning U, Tienari PJ, Hartmann T, Masters CL, Beyreuther K, Förstl H (1993) Apolipoprotein E epsilon 4 alleles and Alzheimer´s disease. Lancet 342, 1308-1309 .

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