Research Group Principal Investigator

    Mikael Knip, MD, PhD, Professor of Pediatrics, Chief Physician

    Tel: +358 9 471 72701
    E-mail: mikael.knip [at]

    Institute of Clinical Medicine Children´s Hospital
    Department of Paediatrics
    PL 22, Stenbäckinkatu 11
    00014 University of Helsinki

Diabetes and Obesity Research Program contact information

Postal Address
Research Programs Unit
Diabetes and Obesity
Research Program
P.O.Box 63, Haartmaninkatu 8
FI-00014 University of Helsinki

Visiting Address
Biomedicum 1
Haartmaninkatu 8
00290 Helsinki

Tel. +358 2941 911 (tel. exchange)
Fax + 358 2941 26382
Email name.lastname [at]

Pathogenesis, Prediction and Prevention of Childhood Type 1 Diabetes (PEDIA) - Presentation

Group Mikael Knip PEDIA Group: Markku Latva-Koivisto, Iiris Ollila, Sinikka Helander, Mevlida Kararic (upper row)
Heli Siljander,  Michaela Selen, Taina Härkönen (middle row)
Juho Hämäläinen, Mikael Knip (lower row), Heli Suomalainen (not present in picture)

Professor Knip's research group has contributed to the present understanding of the diabetic disease process and reported important findings in the area of type 1 diabetes (T1D) prediction and prevention. The team leader's publication record in the field of beta-cell autoimmunity and T1D is impressive.

Type 1 diabetes is the most common serious disease among children and adolescents in the European countries. Globally, the incidence is highest in the Northern Europe, but the incidence rate is continuously increasing all over our continent. The number of new cases with type 1 diabetes among European children younger than five years of age has been predicted to double between 2005 and 2020. The aetiology is largely unknown; no efficient primary prevention is available and nobody has so far been cured.

In spite of heavy treatment with multiple daily insulin injections, adapted to regular meals with suitable content and monitored by several daily blood glucose tests, it is in practice impossible to avoid both life-threatening acute complications with sudden unconsciousness, and late diabetes complications affecting kidney, nerves and heart and leading to disabilities and increased mortality.

The disease process starts months and years before any symptoms of diabetes appear. Deeper insights are needed into the process resulting in clinical disease to be able to develop effective preventive measures. New technologies provide promising prospects for generating novel knowledge that can be translated into successful prevention and treatment.

The group has experience from large scale international research projects. The attached brochure (PDF 1.53 MB) outlines Professor Knip's current research projects.