Mikael Knip, MD, PhD, Professor of Pediatrics, Chief Physician
Tel: +358 9 471 72701
E-mail: mikael.knip [at] helsinki.fi
Institute of Clinical Medicine Children´s Hospital
Department of Paediatrics
PL 22, Stenbäckinkatu 11
00014 University of Helsinki
Research Programs Unit
Diabetes and Obesity
P.O.Box 63, Haartmaninkatu 8
FI-00014 University of Helsinki
Tel. +358 2941 911 (tel. exchange)
Fax + 358 2941 26382
Email name.lastname [at] helsinki.fi
Pathogenesis, Prediction and Prevention of Childhood Type 1 Diabetes (PEDIA) - Presentation
PEDIA Group: Markku Latva-Koivisto, Iiris Ollila, Sinikka Helander, Mevlida Kararic (upper row)
Heli Siljander, Michaela Selen, Taina Härkönen (middle row)
Juho Hämäläinen, Mikael Knip (lower row), Heli Suomalainen (not present in picture)
Professor Knip's research group has contributed to the present understanding of the diabetic disease process and reported important findings in the area of type 1 diabetes (T1D) prediction and prevention. The team leader's publication record in the field of beta-cell autoimmunity and T1D is impressive.
Type 1 diabetes is the most common serious disease among children and adolescents in the European countries. Globally, the incidence is highest in the Northern Europe, but the incidence rate is continuously increasing all over our continent. The number of new cases with type 1 diabetes among European children younger than five years of age has been predicted to double between 2005 and 2020. The aetiology is largely unknown; no efficient primary prevention is available and nobody has so far been cured.
In spite of heavy treatment with multiple daily insulin injections, adapted to regular meals with suitable content and monitored by several daily blood glucose tests, it is in practice impossible to avoid both life-threatening acute complications with sudden unconsciousness, and late diabetes complications affecting kidney, nerves and heart and leading to disabilities and increased mortality.
The disease process starts months and years before any symptoms of diabetes appear. Deeper insights are needed into the process resulting in clinical disease to be able to develop effective preventive measures. New technologies provide promising prospects for generating novel knowledge that can be translated into successful prevention and treatment.
The group has experience from large scale international research projects. The attached brochure (PDF 1.53 MB) outlines Professor Knip's current research projects.
- Faculty of Medicine
- Biomedicum Helsinki
- Institute of Clinical Medicine
- National Institute for Health and Welfare (THL)
- Graduate Schools
- Research on Type 1 Diabetes DIABIMMUNE
- Diabetes Prediction and Prevention (DIPP) Study
- Trial to Reduce IDDM in the Genetically at Risk (TRIGR)
- Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research
- PEVNET Consortium
Research areas and projects
- University of Helsinki Digital Theses
- Research database TUHAT