Mikael Knip, MD, PhD, Professor of Pediatrics, Chief Physician
Tel: +358 9 471 72701
E-mail: mikael.knip [at] helsinki.fi
Institute of Clinical Medicine Children´s Hospital
Department of Paediatrics
PL 22, Stenbäckinkatu 11
00014 University of Helsinki
Research Programs Unit
Diabetes and Obesity
P.O.Box 63, Haartmaninkatu 8
FI-00014 University of Helsinki
Tel. +358 2941 911 (tel. exchange)
Fax + 358 2941 26382
Email name.lastname [at] helsinki.fi
Pathogenesis, Prediction and Prevention of Childhood Type 1 Diabetes (PEDIA) - Research
PEDIA Group members: Sinikka Helander, Berta Davydova, Mikael Knip, Juho Hämäläinen
Research on Type 1 Diabetes DIABIMMUNE
In the EU-funded DIABIMMUNE study led by Dr. Knip as the Principal Investigator we are currently testing the hygiene hypothesis in T1D and other immune-mediated diseases by monitoring initially non-diabetic infants and young children in Russian Karelia, Estonia and Finland for genetic susceptibility, early infections, use of antibiotics, gut microbiota, dietary factors, maturation of the immune system and the emergence of signs of autoimmunity. Read more about the DIABIMMUNE project.
Diabetes Prediction and Prevention (DIPP) Study
In the Diabetes Prediction and Prevention (DIPP) project, which is a birth cohort study, we plan to expand our studies exploring gene-gene and gene-environmental interactions in the diabetic disease process. The DIPP project is a collaborative study of three Finnish university hospitals (Turku, Tampere, and Oulu). Read more about DIPP research areas and collaboration projects.
Trial to Reduce IDDM in the Genetocally at Risk (TRIGR)
The TRIGR study aims at assessing whether weaning to a highly hydrolyzed casein formula in infancy will later prevent T1D in subjects with at least one affected family member and carrying a HLA genotype conferring diabetes susceptibility. 77 centres in Canada, the United States, Europe and Australia are involved in TRIGR. Additional information is available from the international TRIGR website.
Molecular Systems Immunology and Physiology Research Group
Dr. Knip is the Deputy Director of the Centre of Excellence (CoE) in Molecular Systems Immunology and Physiology Research, which has been awarded funding from the Academy of Finland for a 6-year period starting at the beginning of 2012. Professor Matej Oresic (VTT Technical Research Centre of Finland) is the Director of the Centre, and Professor Riitta Lahesmaa (University of Turku), Professor Anjana Rao (University of Turku and La Jolla Institute for Allergy and Immunology), Professor Olli Simell (University of Turku), and Professor Harri Lähdesmäki (Aalto University) are the other senior investigators in the Centre. The overall objective is to build a series of models and translational biomarkers that will foster the understanding of mechanisms of autoimmune diseases, from systemic to cellular levels, thus contributing to disease prediction, prevention and therapy. The centre will utilize the biological samples collected within the DIABIMMUNE and DIPP studies as one source of clinical material. Read more about the Molecular Systems Immunology and Physiology Research Group.
The attached brochure (PDF 1.53 MB) also describes Professor Knip's current research projects.
- Faculty of Medicine
- Biomedicum Helsinki
- Institute of Clinical Medicine
- National Institute for Health and Welfare (THL)
- Graduate Schools
- Research on Type 1 Diabetes DIABIMMUNE
- Diabetes Prediction and Prevention (DIPP) Study
- Trial to Reduce IDDM in the Genetically at Risk (TRIGR)
- Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research
- PEVNET Consortium
Research areas and projects
- University of Helsinki Digital Theses
- Research database TUHAT