Research Group Principal Investigator

    Tiinamaija Tuomi, MD, PhD, associate professor (docent)

    Tel:+358 9 191 25725
    E-mail: tiinamaija.tuomi [at] helsinki.fi

    Research Programs Unit
    C323b
    P.O.Box 63, Haartmaninkatu 8
    FI-00014 University of Helsinki
    Finland

Botnia-project office in Helsinki

    Laura Impivaara

    Tel: +358 9 471 1870
    GSM: +358 50 428 7811
    E-mail: ext-laura.impivaara [at] hus.fi

Diabetes and Obesity Research Program contact information

Postal Address
Research Programs Unit
Diabetes and Obesity
Research Program
P.O.Box 63, Haartmaninkatu 8
FI-00014 University of Helsinki
Finland

Visiting Address
Biomedicum 1
Haartmaninkatu 8
00290 Helsinki

Tel. +358 2941 911 (tel. exchange)
Fax + 358 2941 26382
Email name.lastname [at] helsinki.fi

Botnia Study - Presentation

Botnia group membersBotnia Group: Merja Lahtinen, Virve Lundgren, Mette Anderssen, Tiinamaija Tuomi (principal investigator), Laura Impivaara, Paula Kokko.

The research of the Botnia Study Group aims at characterizing the genetic and environmental factors predisposing to diabetes and its complications. In addition to unraveling the complex interacting metabolic pathways, we hope to find tools for individualized prevention and treatment of diabetes. The Botnia Study is led by Prof. Leif Groop and Dr. Tiinamaija Tuomi.

Type 2 diabetes (T2D) is a complex disease caused by a multitude of interacting genes and environmental factors. Large numbers of patients and families with diabetes as well as large population-based studies are necessary for unraveling this interaction. The Botnia Family Study includes approximately 15,000 subjects from more than 3,000 families. Roughly 4,000 of them have diabetes, mostly type 2 diabetes, but families with monogenic diabetes, type 1 diabetes and mixed families with both T1D and T2D are also included.

We published a genome-wide scan in patients with type 2 diabetes and controls in 2007 and to date, more than 40 genes have been associated with type 2 diabetes and its subphenotypes in international collaborative projects where we have participated. The Botnia Prospective Study includes 3300 initially non-diabetic subjects (relatives and spouses of T2D patients) who have been followed for 8-10 years. Together with traditional risk factors, such as high body-mass index and slightly raised plasma glucose, family history of diabetes increased the risk of developing diabetes. More importantly, we could show that a combination of several risk variants in the identified genes increased the risk of developing diabetes.

More information on our research is available on the Botnia Study webpages.