| Day 1. Sunday, 31st May 2009 |
| 13.00 – 15.00 |
Arrival to Hanasaari Cultural Centre,
Registration, poster set up |
|
15.00 |
Opening of the meeting:
Krister Höckerstedt (Chairman of the Medical Board of the Sigrid Jusélius Foundation) |
|
| 15.10 |
Opening of the scientific meeting
Prof Anu Suomalainen-Wartiovaara
(University of Helsinki) |
|
| |
Music: Käpylä Junior Strings |
|
| |
Plenary lecture
Chair: Anu Suomalainen-Wartiovaara |
|
15.45 – 16.25 |
Tom Kirkwood (Newcastle University)
Why brains deteriorate with age: evolutionary origins of intrinsic neurodegeneration |
|
| |
Mechanisms of Aging and Longevity
Chair: Hans Spelbrink |
|
16.30 – 17.00 |
Linda Partridge (University College London)
Longevity in flies & mice |
|
| 17.05 – 17:35 |
Della David (University of California, San Francisco)
Protein aggregation as an inherent part of ageing |
|
| 17:40 – 18:10 |
Eric Verdin (University of California, San Francisco)
Sirtuins and mitochondrial metabolism |
|
| 18.15 – 18.25 |
Short talk:
Alberto Sanz (University of Tampere)
Unexpected regulation of lifespan by mitochondrial function
|
|
| 19:00 – |
Welcome Dinner |
|
| 20.30 – |
Get together at posters |
|
| |
| Day 2. Monday, 1st June 2009 |
| |
Mechanisms of Aging and Longevity continued
Chair: Kalervo Hiltunen |
|
09.00 –09.30 |
Adam Antebi (Baylor College of Medicine)
Steroid hormone regulation of longevity |
|
| 09.35 – 10.05 |
Thomas Nyström (University of Gothenburg)
Mechanisms for generating a rejuvenated progeny |
|
| 10:10 – 10:40 |
Siegfried Hekimi (McGill University)
ROS & longevity |
|
| 10:45 – 11:15 |
Tea & Coffee |
|
| |
Chair: Iiris Hovatta |
|
11.15 – 11.25 |
Short talks:
Malin Hernebring (University of Gothenburg ) Differentiation induced rejuvenation in mouse |
|
| 11.30 – 11.40 |
Carina Holmberg ( University of Helsinki) : Live imaging and quantification of proteasome activity in vivo |
|
| 11.45 – 11.55 |
Alexander Kastaniotis (University of Oulu ) : Synthetic petite interactions of compromised mitochondrial fatty acid synthesis |
|
| 12.00 – 12.10 |
Iain Rogers (University College London ): I nducible model of Alzheimer s Disease in the fruit fly |
|
| 12.15 – 12.25 |
Emil Ylikallio (University of Helsinki): Mitochondrial transcription factor A (TFAM) and Twinkle helicase regulate mitochondrial DNA copy number by distinct mechanisms |
|
| 12.30 – 12.40 |
Marko Kervinen (University of Oulu): The effect of pathogenic mitochondrial mutations on degeneration and longevity |
|
| |
|
|
| 12.45– 14.00 |
Lunch |
|
| |
Mechanisms of aging & degenerative disease
Chair: Kari Majamaa |
|
14.00 – 14.30 |
Nils-Göran Larsson (Karolinska Institute)
Regulation of mtDNA expression in disease and ageing
|
|
| 14.35 – 15.05 |
Tomas Prolla (University of Wisconsin)
mtDNA maintenance and premature aging |
|
| 15.10– 15.40 |
Anu Suomalainen-Wartiovaara (University of Helsinki). Physiological consequences of mtDNA maintenance defects |
|
| 15:45 – 16:15 |
Tea & Coffee and refreshments |
|
| |
Chair: Eeva-Liisa Eskelinen |
|
16.15 – 16.25 |
Short talk:
Henna Tyynismaa (University of Helsinki)
Mitochondrial myopathy elicits a global starvation response through a hormonal serum factor
|
|
| 16.30 – 17.00 |
Ana Maria Cuervo (Albert Einstein College of Medicine) Neurodegeneration & autophagy |
|
| 17.05 – 17.35 |
Brian Kennedy (University of Washington)
Dietary restriction & longevity |
|
17.40 – |
Poster viewing |
|
| 19.00 – |
Dinner |
|
| 20.00 – |
Sauna available for hotel visitors |
|
| 20.00 – |
For everyone: Bar, Music and Dance with the
"The Sisters and the Big Fat Family" |
|
|
| Day 3. Tuesday 2nd June 2009 |
| |
Mechanisms of neurodegenerative disease
Chair: Brendan Battersby
|
|
09.00 – 09.30 |
Laurence Bindoff (University of Bergen)
POLG in neurodegeneration |
|
| 09.35 – 10.05 |
Carlos T. Moraes (University of Miami)
Functional and Molecular Consequences of OXPHOS Defects in Neurodegeneration
|
|
| 10.10 – 10.40 |
Eric Shoubridge (Montreal Neurological Institute, McGill University) Lost in (mitochondrial) translation |
|
10.45 – 11.15 |
Tea & Coffee |
|
| |
Chair: Anna-Elina Lehesjoki |
|
11.15 – 11.45 |
Massimo Pandolfo (University of Brussels)
Friedreich’s ataxia & pathogenesis
|
|
| 11.50 – 12.20 |
Giovanni Manfredi (Cornell University)
Amyotrophic lateral sclerosis & mitochondrial dysfunction |
|
| 12.25 – 12.55 |
Frederic Saudou (Institut Curie)
Huntington’s disease: huntingtin function and the control of intracellular trafficking |
|
13.00 – 14.30 |
Lunch |
|
| |
Chair: Pentti Tienari |
|
14.30 – 15.00 |
David Chan (Caltech)
The role of mitochondrial fusion in maintaining mtDNA |
|
| 15.05 – 15.35 |
Ella Bossy-Wetzel (University of Central Florida) Mutant huntingtin mediates neuronal injury by mitochondrial fragmentation |
|
| 15:40 – 16:10 |
John Hardy (University College London)
Genome, transcriptome and neurodegeneration |
|
16.15– 16.35 |
Tea & Coffee |
|
| |
Chair: Dan Lindholm |
|
1.35– 17.05 |
Andrew Singleton (National Institute of Aging, NIH) Molecular genetics of Parkinson’s disease |
|
| 17.10– 17.40 |
Ming Guo (University of California, Los Angeles)
Mitochondrial pathways to Parkinson's disease, lessons from the fly |
|
18.15 – 22.00 |
Helsinki Cruise & Dinner |
|
|
| Day 4. Wednesday 3rd June 2009 |
| |
Approaches towards intervention
Chair: Eero Castren
|
|
09.00 – 09.30 |
Howy Jacobs (University of Tampere)
Molecular by-pass therapy for mitochondrial dysfunction
|
|
| 09.35 – 10.05 |
Mike Murphy (MRC Mitochondrial Biology Unit) Targeting bioactive molecules to mitochondria |
|
| 10.10 – 10.40 |
Mart Saarma: (University of Helsinki)
Neurodegeneration & growth factors |
|
10.45 – 11.15 |
Coffee |
|
| |
Taking it all together: Plenary lecture
Chair: Howy Jacobs
|
|
11.15 – 11.55 |
Leonard Guarente (Massachusetts Institute of Technology)
Mechanisms of aging, neurodegeneration and mitochondrial dysfunction - common denominators and sites of intervention |
|
12.00 |
Closing of the meeting
Howy Jacobs |
|
12.15 – 13.30 |
Lunch |
|
| |
The End of the program in Hanasaari Cultural Centre |
|
| |
|
|
| **** |
|
|
