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Contact Information:

Project Coordinator

Petri Salven
M.D., Ph.D., Adjunct Professor, Research Director

Molecular Cancer Biology Program
Biomedicum Helsinki
PO Box 63 (Haartmaninkatu 8)
FI-00014 University of Helsinki
Finland
Tel. +358 9 191 25384
Fax. +358 9 191 25664

e-mail :
firstname.surname@helsinki.fi

Participants:

Salven Lab Alitalo Lab Taipale Lab ten Dijke Lab Naldini Lab

Pucci F, Venneri MA, Biziato D, Nonis A, Moi D, Sica A, Di Serio C, Naldini L, De Palma M. (2009). A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes (TEMs), blood "resident" monocytes and embryonic macrophages suggests common functions and developmental relationships.
Blood 2009 Apr 21. [Epub ahead of print]

De Palma M, Mazzieri R, Politi LS, Pucci F, Zonari E, Sitia G, Mazzoleni S, Moi D, Venneri MA, Indraccolo S, Falini A, Guidotti LG, Galli R, Naldini L. (2008). Tumor-targeted interferon- alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 14:299-311.

Purhonen S., Palm J., Rossi D., Kaskenpää, N., Rajantie I., Ylä-Herttuala S., Alitalo K., Weissman I.L., and Salven P. (2008). Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A 105:6620-5.

Varjosalo, M., Bjorklund, M., Cheng, F., Syvanen, H., Kivioja, T., Kilpinen, S., Sun, Z., Kallioniemi, O., Stunnenberg, H. G., He, W. W., et al. (2008). Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 133, 537-548.

Itoh S and ten Dijke P. (2007). Negative regulation of TGF-b receptor/Smad signal transductionCurr Opion. Cell Biol. 19:176-84.

Varjosalo M, Taipale J. (2007). Hedgehog signaling.  J Cell Sci. 120(Pt 1):3-6. Review

ten Dijke P, Arthur HM. (2007). Extracellular control of TGFbeta signalling in vascular development and disease.  Nat Rev Mol Cell Biol. 8:857-69. Review

Venneri MA, De Palma M, Ponzoni M, Pucci F, Scielzo C, Zonari E, Mazzieri R, Doglioni C, Naldini L. (2007). Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood. 109:5276-85.

De Palma M, Murdoch C, Venneri MA, Naldini L, Lewis CE. (2007).
Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications. Trends Immunol 28:519-24.

Lewis CE, De Palma M, Naldini L. (2007). Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res 67:8429-32.

Noda D, Itoh S, Watanabe Y, Inamitsu M, Dennler S, Itoh F, Koike S, Danielpour D, ten Dijke P, Kato M. (2006). ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-b/Smad-induced growth arrest of prostate cells. Oncogene 25:5591-600.

He Y, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, Alitalo K, Min W. (2006). Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest 116; 2344-55.

Bjorklund M, Taipale M, Varjosalo M, Saharinen J, Lahdenpera J, Taipale J. (2006). Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature 439; 1009-13.

Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C, Sergi LS, Benedicenti F, Ambrosi A, Di Serio C, Doglioni C, von Kalle C, Naldini L.  (2006). Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol 24; 687-96.

Brown BD, Venneri MA, Zingale A, Sergi LS, Naldini L. (2006). Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nat Med 12; 585-91.

Hallikas O, Palin K, Sinjushina N, Rautiainen R, Partanen J, Ukkonen E, Taipale J.  (2006). Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 124; 47-59.

Deckers M, van Dinther M, Buijs J, Que I, Lowik C, van der Pluijm G, ten Dijke P. (2006). The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 66; 2202-9.

De Palma M, Venneri MA, Galli R, Sergi LS, Politi LS, Sampaolesi M, Naldini L. (2005). Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 3; 211-26.

He Y, Rajantie, Ilmonen M, Makinen T, Karkkainen MJ, Haiko P, Salven P, Alitalo K. (2004). Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Res 64; 3737-3740.

Rajantie I. , Ilmonen M., Alminaite A., Ozerdem U. , Alitalo K., Salven P. (2004). Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood 104; 2084-6.

Lebrin F, Goumans MJ, Jonker L, Carvalho RL, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM, ten Dijke P.(2004). Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J 23; 4018-28.

Uutela M, Wirzenius M, Paavonen K, Rajantie I, He Y, Karpanen T, Lohela M, Wiig H, Salven P, Pajusola K, Eriksson U, Alitalo K. (2004). PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood 104; 3198-204.

Page updated July 1, 2009

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