Contact Information:
Markku Heikinheimo
M.D., Ph.D.
pediatrician, pediatric hematologist, Professor of Pediatrics
Head of the National Clinical Graduate School
Head of the Clinical Graduate School in Pediatrics and Obstetrics/Gynecology (PEGY) (co-chaired with prof. Jorma Paavonen)
Laboratory:
Biomedicum Helsinki 2U
P.O. Box 63 (Tukholmankatu 8)
00014 University of Helsinki
Finland
Office:
Children's Hospital
P.O. Box 22
00014 University of Helsinki
Finland
Tel. +358 9 471 71983
Fax +358 9 471 71947
E-mail:
firstname.surname@helsinki.fi
Visiting professor of pediatrics, Division of Pediatric
Hematology / Oncology,
Dept. of Pediatrics,
Washington University
Medical School,
St. Louis, MO, USA
|
|
Selected Publications
The group's publications on the Research Database Tuhat
- Viger RS, Guittot SM, Anttonen M, Wilson DB, Heikinheimo M. Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease. Mol Endocrinol. 2008 Jan 3; [Epub ahead of print]
- Bielinska M, Seehra A, Toppari J, Heikinheimo M, Wilson DB. GATA-4 is required for sex steroidogenic cell development in the fetal mouse. Dev Dyn. 2007 Jan;236(1):203-13.
- Kung C, Pingel JT, Heikinheimo M, Klemola T, Varkila K, Yoo LI, Vuopala K, Poyhonen M, Uhari M, Rogers M, Speck SH, Chatila T, Thomas ML Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med. 2000 Mar;6(3):343-5.
More selected publications published by the group members
Leila Unkila-Kallio
- Unkila-Kallio L, Leminen A, Tiitinen A, Ylikorkala O. Nationwide data on falling incidence of ovarian granulosa cell tumour concomitantly with increasing use of ovulation inductors. Hum Reprod 1998; 13: 2828-30.
- Unkila-Kallio L, Tiitinen A, Wahlströ m T, Lehtovirta P, Leminen A. Reproductive features in women developing ovarian granulosa cell tumour at a fertile age. Hum Reprod 2000; 15:589-93.
- Unkila-Kallio L, Vuorela-Vepsäläinen P, Tiitinen A, Halmesmäki E, Ylikorkala O. No cyclicity in serum vascular endothelial growth factor during normal menstrual cycle but significant luteal phase elevation during an in vitro fertilization program. Am J Reprod Imm 2000; 43:25-30.
Mikko Anttonen
- Anttonen M, Unkila-Kallio L, Leminen A, Butzow R, and Heikinheimo M: High GATA-4 expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors. J Clin Endocrinol Metab 2005 Dec;90(12):6529-35.
- Jamieson S, Butzow R, Andersson N, Alexiadis M, Unkila-Kallio M, Heikinheimo M, Fuller PJ, and Anttonen M: The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. Mod Pathol 2010 Nov;23(11):1477-85.
- Benayoun BA, Georges AB, L'Hôte D, Andersson N, Dipietromaria A, Todeschini A-L, Caburet S, Bazin C, Anttonen M, and Veitia RA: FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by SIRT1 deacetylase. Hum Mol Genet 2011. Epub Feb 23.
Noora Anderssoni
- Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase. Benayoun BA, Georges AB, L'hôte D, Andersson N, Dipietromaria A, Todeschini AL, Caburet S, Bazin C, Anttonen M, Veitia RA. Hum Mol Genet. 2011 Feb 23.
- The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. Jamieson S, Butzow R, Andersson N, Alexiadis M, Unkila-Kallio L, Heikinheimo M, Fuller PJ, Anttonen M. Mod Pathol. 2010 Nov;23(11):1477-85.
Antti Kyrönlahti
- Kyrönlahti A, Euler R, Bielinska M, Schoeller E, Moley K, Toppari J, Heikinheimo M, and Wilson D. GATA4 regulates Sertoli cell function and fertility in adult male mice. Mol Cell Endocrinol. 2011 Feb 10;333(1):85-95.
- Kyrönlahti A, Vetter M, Euler M, Bielinska M, Jay P, Anttonen M, Heikinheimo M, and Wilson D. GATA4 Deficiency Impairs Ovarian Function in Adult Mice. Biol Reprod. 2011 Jan 19. [Epub ahead of print].
Kyrönlahti A*, Kauppinen M*, Lind E, Unkila-Kallio L, Butzow R, Klefström J, Wilson D, Anttonen M, and Heikinheimo M: GATA-4 protects granulosa cell tumors from TRAIL induced apoptosis. Endocr Relat Cancer. 2010 Jul 28;17(3):709-17.
Anniina Färkkilä
- Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 are highly expressed in ovarian granulosa cell tumors. Färkkilä A, Anttonen M, Pociuviene J, Leminen A, Butzow R, Heikinheimo M, Unkila-Kallio L. Eur J Endocrinol. 2011 Jan;164(1):115-22. Epub 2010 Nov 1.
Marjut Kauppinen
- Kyrönlahti A*, Kauppinen M*, Lind E, Unkila-Kallio L, Bützow R, Klefström J, Wilson DB, Anttonen M, Heikinheimo M. GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocr Relat Cancer, 2010, 17:709-717. * equal contribution
- Jääskeläinen M, Nieminen A, Pökkylä RM, Kauppinen M, Liakka A, Heikinheimo M, Vaskivuo TE, Klefström J, Tapanainen JS. Regulation of cell death in human fetal and adult ovaries-Role of Bok and Bcl-X(L). Mol Cell Endocrinol, 2010 epub Jul 29.
Helka Parviainen
- Jääskeläinen M, Prunskaite-Hyyryläinen R, Naillat F, Parviainen H, Anttonen M, Heikinheimo M, Liakka A, Ola R, Vainio S, Vaskivuo TE, Tapanainen JS. Wnt4 is expressed in human fetal and adult ovaries and its signaling contributes to ovarian cell survival. Molecular and Cellular Endocrinology 2010 Apr 12;317(1-2):106-11.
- Anttonen M*, Parviainen H*, Kyrönlahti A, Bielinska M, Wilson DB, Ritvos O, Heikinheimo M: GATA-4 is a granulosa cell factor employed in inhibin-α activation by the TGF-β pathway. Journal of Molecular Endocrinology 2006 Jun;36:557-68. *equal contribution
- Bielinska M, Parviainen H, Porter-Tinge SB, Kiiveri S, Genova E, Rahman N, Huhtaniemi IT, Muglia LJ, Heikinheimo M, Wilson DB: Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor. Endocrinology 2003 Sep;144(9):4123-33.
Tea Soini
- Soini T*, Haveri H*, Elo J, Kauppinen M, Kyrönlahti A, Salo MK, Lohi J, Andersson LC, Wilson DB, Heikinheimo M. Transcription Factor GATA-4 Is Expressed in Childhood Liver Tumors. Submitted. * equal contribution
Ilkka Ketola
- Ketola I, Rahman N, Toppari J, Bielinska M, Porter-Tinge SB, Tapanainen JS, Huhtaniemi IT, Wilson DB ja Heikinheimo M. Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis. Endocrinology 1999 140:1470-1480.
- Ketola I, Pentikäinen V, Vaskivuo T, Ilvesmäki V, Herva R, Dunkel L, Tapanainen JS, Toppari J and Heikinheimo M. Expression of transcription factor GATA-4 during human testicular development and disease. Journal of Clinical Endocrinology and Metabolisim 2000 85:3925-31.
- Ketola I, Anttonen M, Vaskivuo T, Tapanainen JS, Toppari J and Heikinheimo M. Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis. European Journal of Endocrinology 2002 147:397-406.
Sanne Kiiveri
- Kiiveri S, Liu J, Arola J, Heikkilä P, Kuulasmaa T, Lehtonen E, Voutilainen R, Heikinheimo M. Transcription factors GATA-6, SF-1, and cell proliferation in human adrenocortical tumors.Mol Cell Endocrinol. 2005 Apr 15;233(1-2):47-56.
- Rahman NA, Kiiveri S, Rivero-Müller A, Levallet J, Vierre S, Kero J, Wilson DB, Heikinheimo M, Huhtaniemi I. Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4.Mol Endocrinol. 2004 Oct;18(10):2553-69.
- Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M. Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology. 2002 Aug;143(8):3136-43.
Susanna Mannisto
- Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors. Salonen J, Rajpert-De Meyts E, Mannisto S, Nielsen JE, Graem N, Toppari J, Heikinheimo M.Eur J Endocrinol. 2010 Mar;162(3):625-31. Epub 2009 Dec 7.
- GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Jacobsen CM, Mannisto S, Porter-Tinge S, Genova E, Parviainen H, Heikinheimo M, Adameyko II, Tevosian SG, Wilson DB. Dev Dyn. 2005 Oct;234(2):355-62.
- Transcription factors GATA-4 and GATA-6, and their potential downstream effectors in ovarian germ cell tumors. Mannisto S, Butzow R, Salonen J, Leminen A, Heikinheimo O, Heikinheimo M. Tumour Biol. 2005 Sep-Oct;26(5):265-73. Epub 2005 Aug 17.
Hanna Haveri
- Haveri H, Ashorn M, Iltanen S, Wilson DB, Andersson LC, Heikinheimo M. Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1. J Clin Immunol, 2009:29(4):444-53.
- Haveri H, Westerholm-Ormio M, Lindfors K, Mäki M, Savilahti E, Andersson LC, Heikinheimo M: Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. BMC Gastroenterol, 2008:11;8:9.
- Divine JK, Staloch LJ, Haveri H, Rowley CW, Heikinheimo M, Simon TC: Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene. Am J Physiol Gastrointest Liver Physiol, 2006:291(2);297-306.
Jonna Salonen
- Mannisto S, Butzow R, Salonen J, Leminen A, Heikinheimo O, Heikinheimo M. Transcription factors GATA-4 and GATA-6, and their potential downstream effectors in ovarian germ cell tumors. Tumour Biol 2005;26:265-273.
- Salonen J, Leminen A, Stenman UH, Butzow R, Heikinheimo M, Heikinheimo O. Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. Tumour Biol 2008;29(1):50-6.
Page updated
October 4, 2011
Mail to Webmaster |
