Infection and inflammation:
- Human papillomavirus phase 3 efficacy trials have been extremely successful. The HPV research group enrolled approximately 7,000 young women in the 2 global efficacy trials. The results have been extremely convincing showing that the vaccines are 100% efficacious in preventing high grade cervical, vaginal or vulvar precancer in unexposed women. A community randomized Phase 4 HPV vaccine effectiveness trial of the best vaccination therapy has just started in Finland; young women have been enrolled to participate in the study. Recommendations of vaccine implementation in Finland have just been published
- A large clinical trail is ongoing of the development of better biomarkers for preterm birth.
- An outpatient clinic for HIV positive women has been established 15 years ago and produces important information of contraception, reproductive health and morbidity of these women.
- Registry linkages are effectively utilized in clinical epidemiologic research. For instance, we have reported that any surgical treatment of cervical intraepithelial neoplasia significantly increases the risk for preterm birth. Evaluation and development of predictors for abnormal placentation (placental abruption, placenta accreta) are ongoing. More about the project ->
- Single embryo transfer in IVF is emphasized and implemented.
- Prediction of chlamydial tubal factor infertility by combination of new biomarkers in order to avoid surgery.
- Safe medical abortion has been evaluated.
- Pregnancy associated morbidity predicts cardiovascular diseases and other disease morbidity in later life which is an important window opportunity for disease prevention.
- Hormonal IUD is more cost-effective than hysterectomy in the treatment of menorrhagia. Hysterectomy rates have already decreased in Finland by 40% in just few years which proves the impact of our randomized trial in which all university departments participated. A 10-year follow-up is ongoing with new research questions.
- Hormonal replacement therapy can be improved to maximise health benefits.
More about the project ->
Breast cancer and ovarian cancer
- These are the two most dearly cancers in women. Genetic and molecular diagnosis can be improved by utilizing large tissue biobanks. This may ultimately lead to better therapeutic modalities. More about the project ->
- Better understanding of the essential genes in urogenital development may improve classification of ovarian tumors and development of new biomarkers for these tumors. This part of the research program from the Department of Pediatrics strengthens the basic and translational aspects of the Women’s Health program. More about the project ->
13 December, 2012
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