Welcome to group Tyynismaa's pages!

We are interested in the role of aminoacyl-tRNA synthetases in human disease. These ancient enzymes are essential for protein synthesis both in the cytoplasm and in the mitochondria. Defects in the mitochondrial aminoacyl-tRNA synthetases can lead to various tissue-specific mitochondrial disorders such as cardiomyopathy or leukoencephalopathy whereas patient mutations in the cytoplasmic aminoacyl-tRNA synthetases are associated with Charcot-Marie-Tooth neuropathy. We aim to characterize the genetic and molecular mechanisms of these disorders and to develop disease models for them.

 

Affiliations

• Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki
• Department of Medical Genetics, Haartman Institute, Faculty of Medicine, University of Helsinki
• FinMIT - Centre of Excellence of the Academy of Finland: Finnish research unit for mitochondrial biogenesis and disease

 

Funding
The Academy of Finland
Biocentrum Helsinki
Arvo and Lea Ylppö Foundation
University of Helsinki Three-year research grant
Orion-Farmos Research Foundation

 

Page updated January 5, 2012
Webmaster Erika Weckström firstname.lastname [at] helsinki.fi