• Molecular Cancer Biology Program
• Center of Excellence in Cancer Biology
• HBGP - Helsinki Biomedical Graduate Program
• GPBM -
  Helsinki Graduate Program in Biotechnology and Molecular Biology

Contact Information:

Jorma Keski-Oja
M.D., Ph.D., Professor
Molecular Cancer Biology Program
Biomedicum Helsinki
Haartman Institute

PO BOX 63 (Haartmaninkatu 3)
FI-00014 University of Helsinki
Finland

Tel. +358 9 191 25566
Fax. +358 9 191 25610

e-mail :
firstname.surname@helsinki.fi

Secretary Merja Koivulahti

Translational Cancer Biology Researc Program's website has moved.

http://research.med.helsinki.fi/cancerbio/index.html

TGF-ß is an efficient regulator of cell proliferation and extracellular proteolysis. Our main focus is in the biology of latent forms of TGF-ß family growth factors, their association with the extracellular matrix structures by LTBPs (latent TGF-ß binding proteins) and proteolytic release and activation of the latent complexes. A link to the regulation of extracellular proteolysis is via plasminogen activators and metalloproteinases. We have analyzed plasmin mediated processing/activation of gelatinase A, and identified membrane type-1 MMP (MT1-MMP) as a major effector in the cell surface associated activation of gelatinase A

Page updated December 2, 2014

Mail to Webmaster