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Contact Information: Jorma Keski-Oja
Secretary Merja Koivulahti
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Main page
TGF-ß is an efficient regulator of cell proliferation and extracellular proteolysis. Our main focus is in the biology of latent forms of TGF-ß family growth factors, their association with the extracellular matrix structures by LTBPs (latent TGF-ß binding proteins) and proteolytic release and activation of the latent complexes. A link to the regulation of extracellular proteolysis is via plasminogen activators and metalloproteinases. We have analyzed plasmin mediated processing/activation of gelatinase A, and identified membrane type-1 MMP (MT1-MMP) as a major effector in the cell surface associated activation of gelatinase A
Page updated August 17, 2007 |
