• Molecular Cancer Biology Program
• Center of Excellence in Cancer Biology
• HBGP - Helsinki Biomedical Graduate Program
• GPBM -
  Helsinki Graduate Program in Biotechnology and Molecular Biology

Contact Information:

Jorma Keski-Oja
M.D., Ph.D., Professor
Molecular Cancer Biology Program
Biomedicum Helsinki
Haartman Institute

PO BOX 63 (Haartmaninkatu 3)
FI-00014 University of Helsinki
Finland

Tel. +358 9 191 25566
Fax. +358 9 191 25610

e-mail :
firstname.surname@helsinki.fi

Secretary Merja Koivulahti

Translational Cancer Biology Researc Program's website has moved.

http://research.med.helsinki.fi/cancerbio/index.html

• Wempe, F., De-Zolt, S., Koli, K., Bangsow, T., Parajuli, N., Dumitrascu, R., Sterner-Kock, A., Weissmann, N., Keski-Oja, J. and von Melchner, H.: The mutational inactivation of the antioxidant protein Sestrin 2 induces TGF-β signaling and partially rescues pulmonary emphysema in a genetic mouse model of pulmonary emphysema.  Dis. Model Mech., in press, 2009.
• Leppäranta, O., Myllärniemi, M., Salmenkivi, K., Kinnula, V.L., Keski-Oja, J. and Koli, K.: Reduced phosphorylation of the TGF-b signal transducer Smad2 in emphysematous human lung. COPD (J. Chron. Obstr. Pulm. Dis.) 6: 234-241, 2009.
• Vehviläinen, P., Hyytiäinen, M. and Keski-Oja, J.: Matrix association of latent TGF-bbinding protein-2 (LTBP-2) is dependent on fibrillin-1. J. Cell Physiol. 221: 586-593, 2009.
• Tritschler, I., Gramatzki, D., Capper, D., Mittelbronn, M., Saharinen, J., Wick, W., Keski-Oja, J., and Weller, M.: Modulation of TGF-b activation by latent TGF-b-binding protein 1 in human malignant glioma cells. Int. J. Cancer,125: 530-540, 2009.
• Lehti, K., Rose, N.F., Valavaara, S., Weiss, S.J. and Keski-Oja, J.: MT1-MMP promotes vascular smooth muscle cell dedifferentiation through LRP1 processing.  J. Cell Sci. 122: 126-135, 2009
• Manicone, A.M., Birkland T.P., Lin, M., Betsuyaku, T., van Roijen, N.,  Lohi,  J., Keski-Oja, J., Wang, Y., Skerrett, S.J. and Parks W.C.: Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J. Immunol. 182:3866-3876, 2009.
• Hakulinen J., Sankkila, L., Sugiyama N., Lehti, K. and Keski-Oja, J.:   Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes, J. Cell. Biochem. 105: 1211-1218, 2008.
• Koli, K., Ryynänen, M.J. and Keski-Oja, J.: Latent TGF-b binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells.  Bone 43: 679-688, 2008.
• Tatti, O., Vehviläinen, P., Lehti, K., and Keski-Oja, J.: MT1-MMP releases latent TGF-b1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1. Exp. Cell Res. 314: 2501-2514, 2008.
• Kantola, A., Keski-Oja, J. and Koli, K.: Fibronectin and heparin binding domains of latent TGF-b binding protein (LTBP)-4 mediate matrix targeting and cell adhesion. Exp. Cell Res. 314: 2488-2500, 2008.
• Myllärniemi M., Vuorinen, K., Pulkkinen, V., Kankaanranta, H., Aine, T., Salmenkivi, K., Keski-Oja, J. Koli, K., and Kinnula, V.L.:  Gremlin localisation and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. J. Pathol. 214: 456-463, 2008.
• Myllärniemi, M., Lindholm, P., Ryynänen, M.J., Kliment, C.R., Salmenkivi, K., Keski-Oja, J., Kinnula, V.L., Oury, T.D., and Koli, K.: Gremlin-mediated decrease in BMP signaling promotes pulmonary fibrosis.  Am. J. Respir. Crit. Care Med. 177: 321-329, 2008.
• Hyytiäinen, M., Koli, K. and Keski-Oja, J.: Biological functions of latent TGF-b binding proteins and activation of TGF-b. In: Beverly Teicher's Methods in Molecular Biology series "Cancer Drug Discovery and Development", “Transforming Growth Factor-beta in Cancer Therapy” (S. Jakovlew, ed.). Humana Press, pp. 57-75, 2008.
• Keski-Oja, J.: Transforming growth factor beta. In: Enclycopedia of Cancer (M. Schwab, ed.), 2nd ed. Springer-Verlag, Berlin, Heidelberg, New York, 5 pp., 2008.
• Koli, K., Myllärniemi, M., Keski-Oja, J. and Kinnula, V.L.: Transforming growth factor-beta in lung fibrosis involves reactive oxygen species. Reactive oxygen species in transforming growth factor-b biology.  Antioxid. Redox Signal., 10: 333-342, 2008.
• Illman, S.A., Lohi, J. and Keski-Oja, J.: Epilysin (MMP-28) - structure, expression and potential functions.  Exp. Dermatol., 17: 897-907, 2008.
• llman, S.A., Lehti, K., Keski-Oja, J. and Lohi, J.: Epilysin (MMP-28) induces TGF-b mediated epithelial to mesenchymal transition in lung carcinoma cells. J. Cell Sci. 119: 3856-3865, 2006.
• Solovyan V.T. and Keski-Oja, J.: Apoptosis of human endothelial cells is accompanied by cleavage of latent TGF- b binding proteins and activation of
  TGF- b. Cell Death Differ. 12: 815-826 , 2005.
• Koli, K., Wempe, F., Sterner-Kock, A., Kantola, A., Komor, M., Hofman, W.-K., von Melchner, H. and Keski-Oja, J.: Disruption of LTBP-4 function reduces TGF- b activation and enhances BMP-4 signaling in the lung. J. Cell Biol., 167 : 123-133 , 2004.
• Wickström , S.A. , Alitalo, K., and Keski-Oja, J.: An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. J. Biol. Chem. 279: 20178-20185, 2004.
• Wang, X., Ma, D., Keski-Oja, J. and Pei , D.: Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network: Identification of DKV582 as a recycling signal. J. Biol. Chem. 279: 9331-9336, 2004.
• Hyytiäinen, M., Penttinen, C. and Keski-Oja, J.: Latent TGF- b binding proteins: Extracellular matrix association and roles in TGF- b activation. Crit. Rev. Clin. Lab. Sci. 41: 1-32, 2004.
• Hyytiäinen, M. and Keski-Oja, J.: Latent TGF- b binding protein LTBP -2 decreases cell adhesion to fibronectin. J. Cell Biol. 163: 1363-1374, 2003.
• Sterner-Kock, A., Thorey, I.S., Koli, K., Wempe, F., Kuhlmeier K., Otte, J., Bangsow, T., Kirchner, T., Jin, S., Keski-Oja, J. and von Melchner, H.: Disruption of the gene encoding the latent transforming growth factor-b binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy and colorectal cancer. Genes Dev. 16: 2264-2273, 2002.
• Wickström S.A. , Alitalo, K. and Keski-Oja, J.: Endostatin associates with integrin a5b1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. Cancer Res. 62: 5580-5589, 2002.

Page updated December 2, 2014

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