CANGENIN - Action BM0703 - Cancer and Control of Genomic Integrity


	Cancer and Control of Genomic Integrity (CANGENIN)

Home - News About CANGENIN Management Committee (MC) Working Groups (WGs) Short-Term Scientific Missions --(STSMs) Training Schools (TSs) Meetings List of participants Publications Links COST COST Action BM0703 Member login		Publications Joint Publications 2011 – March 2012 (two or more CANGENIN PIs) Erdélyi P, Borsos E, Takács-Vellai K, Kovács T, Kovács AL, Sigmond T, Hargitai B, Pásztor L, Sengupta T, Dengg M, Pécsi I, Tóth J, Nilsen H, Vértessy BG, Vellai T. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J Cell Sci. 2011 May 1;124(Pt 9):1510-8. Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS. SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol. 2011 Jan 10;192(1):43-54. Küntziger T, Landsverk HB, Collas P, Syljuåsen RG. Protein phosphatase 1 regulators in DNA damage signaling. Cell Cycle. 2011 May 1;10(9):1356-62. Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS. A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance. EMBO Rep. 2011 Jul 1;12(7):705-12. Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, D'Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O. Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-5. Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis E, Gagos S, Kahata K, Grabusic K, Gkouskou K, Trougakos IP, Kolettas E, Georgakilas AG, Volarevic S, Eliopoulos AG, Zannis-Hadjopoulos M, Moustakas A, Gorgoulis VG. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J Cell Biol. 2011 Dec 26;195(7):1123-40. Sørensen CS, Syljuåsen RG. Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res. 2012 Jan;40(2):477-86. Ugland H, Naderi S, Brech A, Collas P, Blomhoff HK. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy. 2011 Oct;7(10):1199-211. Publications 2011 – March 2012 Aanes H, Winata CL, Lin CH, Chen JP, Srinivasan KG, Lee SG, Lim AY, Hajan HS, Collas P, Bourque G, Gong Z, Korzh V, Aleström P, Mathavan S. Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome Res. 2011 Aug;21(8):1328-38. Abdallah QM, Phillips RM, Johansson F, Helleday T, Cosentino L, Abdel-Rahman H, Etzad J, Wheelhouse RT, Kiakos K, Bingham JP, Hartley JA, Patterson LH, Pors K. Minor structural modifications to alchemix influence mechanism of action and pharmacological activity. Biochem Pharmacol. 2012 Jun 1;83(11):1514-22. Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B, Campo E, Caricasole A, Dahl F, Dermitzakis ET, Enver T, Esteller M, Estivill X, Ferguson-Smith A, Fitzgibbon J, Flicek P, Giehl C, Graf T, Grosveld F, Guigo R, Gut I, Helin K, Jarvius J, Küppers R, Lehrach H, Lengauer T, Lernmark A, Leslie D, Loeffler M, Macintyre E, Mai A, Martens JH, Minucci S, Ouwehand WH, Pelicci PG, Pendeville H, Porse B, Rakyan V, Reik W, Schrappe M, Schübeler D, Seifert M, Siebert R, Simmons D, Soranzo N, Spicuglia S, Stratton M, Stunnenberg HG, Tanay A, Torrents D, Valencia A, Vellenga E, Vingron M, Walter J, Willcocks S. BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol. 2012 Mar 7;30(3):224-6. Al-Assar O, Mantoni T, Lunardi S, Kingham G, Helleday T, Brunner TB Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction. Cancer Biol Ther. 2011 Jun 15;11(12):1028-35. Al-Halabi R, Bou Chedid M, Abou Merhi R, El-Hajj H, Zahr H, Schneider-Stock R, Bazarbachi A, Gali-Muhtasib H. Gallotannin inhibits NFĸB signaling and growth of human colon cancer xenografts. Cancer Biol Ther. 2011 Jul 1;12(1):59-68. doi: 10.4161/cbt.12.1.15715. Al-Ubaidi FL, Schultz N, Egevad L, Granfors T, Helleday T. Castration therapy of prostate cancer results in downregulation of HIF-1α levels.Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1243-8. Alvarez-Fernández M, Halim VA, Aprelia M, Laoukili J, Mohammed S, Medema RH. Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation. J Biol Chem. 2011 Sep 23;286(38):33029-36. Alvarez-Fernández M, Medema RH, Lindqvist A. Transcriptional regulation underlying recovery from a DNA damage-induced arrest. Transcription. 2010 Jul-Aug;1(1):32-5. Andersen IS, Ostrup O, Lindeman LC, Aanes H, Reiner AH, Mathavan S, Aleström P, Collas P. Epigenetic complexity during the zebrafish mid-blastula transition. Biochem Biophys Res Commun. 2012 Jan 27;417(4):1139-44. Anderton JA, Bose S, Vockerodt M, Vrzalikova K, Wei W, Kuo M, Helin K, Christensen J, Rowe M, Murray PG, Woodman CB. The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma. Oncogene. 2011 Apr 28;30(17):2037-43. Andjelkovic T, Bankovic J, Stojsic J, Milinkovic V, Podolski-Renic A, Ruzdijic S, Tanic N. Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patients. Transl Res. 2011 Jan;157(1):19-28. Anensen N, Hjelle SM, Van Belle W, Haaland I, Silden E, Bourdon JC, Hovland R, Taskén K, Knappskog S, Lønning PE, Bruserud O, Gjertsen BT. Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. Oncogene. 2012 Mar 22;31(12):1533-45. Angelova S, Spassova S, Toshkov S, Shivarov V. Chromosomal translocation t(9;22)(p24;q11) appears to be recurrently associated with myeloid malignancy with aggressive course. Leuk Lymphoma. 2011 Sep;52(9):1809-10. Angelova S, Zechev J, Stoimenov A, Spassov B, Romanova M, Shivarov V. A novel t(7;21)(q32;q22) translocation disrupting the RUNX1 gene in an adult patient with acute myeloid leukemia. Leuk Lymphoma. 2011 Dec;52(12):2396-8. Arczewska KD, Baumeier C, Kassahun H, Sengupta T, Bjørås M, Kuśmierek JT, Nilsen H. Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair (Amst). 2011 Feb 7;10(2):176-87 Asselin-Labat ML, Sutherland KD, Vaillant F, Gyorki DE, Wu D, Holroyd S, Breslin K, Ward T, Shi W, Bath ML, Deb S, Fox SB, Smyth GK, Lindeman GJ, Visvader JE. Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol. 2011 Nov;31(22):4609-22. Antonelou MH, Kriebardis AG, Stamoulis KE, Trougakos IP, Papassideri IS. Apolipoprotein J/clusterin in human erythrocytes is involved in the molecular process of defected material disposal during vesiculation.PLoS One. 2011;6(10):e26033. Antonelou MH, Kriebardis AG, Stamoulis KE, Trougakos IP, Papassideri IS. Apolipoprotein J/Clusterin is a novel structural component of human erythrocytes and a biomarker of cellular stress and senescence. PLoS One. 2011;6(10):e26032 Bailly A, Gartner A. Germ cell apoptosis and DNA damage responses, in “The C elegans germ line”, Springer press, 2012, in press. Bajbouj K, Mawrin C, Hartig R, Schulze-Luehrmann J, Wilisch-Neumann A, Roessner A, Schneider-Stock R. P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. *J Neurooncol.* 2012 May;107(3):503-16. Band AM, Laiho M. Crosstalk of TGF-β and estrogen receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia. 2011 Jun;16(2):109-15. Band AM, Laiho M. SnoN oncoprotein enhances estrogen receptor-α transcriptional activity. Cell Signal. 2012 Apr;24(4):922-30. Bao W, Chen M, Zhao X, Kumar R, Spinnler C, Thullberg M, Issaeva N, Selivanova G, Stromblad S. PRIMA-1 (Met) /APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell Cycle. 2011 Jan 15;10(2):301-7. Bartek J, Lukas J. DNA repair: Cyclin D1 multitasks. Nature. 2011 Jun 8;474(7350):171-2. Bauerschmidt C, Woodcock M, Stevens DL, Hill MA, Rothkamm K, Helleday T. Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells. Exp Cell Res. 2011 Feb 1;317(3):330-7. Beider K, Begin M, Abraham M, Wald H, Weiss ID, Wald O, Pikarsky E, Zeira E, Eizenberg O, Galun E, Hardan I, Engelhard D, Nagler A, Peled A. CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth. Exp Hematol. 2011 Mar;39(3):282-92. Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C. Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell. 2012 Mar 14. [Epub ahead of print] Benderska N, Chakilam S, Hugle M, Ivanovska J, Gandesiri M, Schulze-Lührmann J, Bajbouj K, Croner R, Schneider-Stock R. Apoptosis Signalling Activated by TNF in the Lower Gastrointestinal Tract - Review. Curr Pharm Biotechnol. 2011 May 24. [Epub ahead of print] Bereshchenko O, Mancini E, Luciani L, Gambardella A, Riccardi C, Nerlov C. Pontin is essential for murine hematopoietic stem cell survival. Haematologica. 2012 Feb 27. [Epub ahead of print] Beyer U, Dobbelstein M. Non-hominid TP63 lacks retroviral LTRs but contains a novel conserved upstream exon. Cell Cycle. 2011 Jun 15;10(12):1905-11. Beyer U, Moll-Rocek J, Moll UM, Dobbelstein M. Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3624-9. Blandino G, Deppert W, Hainaut P, Levine A, Lozano G, Olivier M, Rotter V, Wiman K, Oren M. Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop. Cell Death Differ. 2012 Jan;19(1):180-3 Blasco MA, Serrano M, Fernandez-Capetillo O. Genomic instability in iPS: time for a break. EMBO J. 2011 Mar 16;30(6):991-3. Blasius M, Forment JV, Thakkar N, Wagner SA, Choudhary C, Jackson SP. A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1. Genome Biol. 2011 Aug 18;12(8):R78. Bogurcu N., Sevimli-Gur C., Ozmen B., Bedir E., Korkmaz K.S., ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. Biochem Biophys Res Commun. 2011 Jun 17;409(4):738-44. Borsos E, Erdélyi P, Vellai T. Autophagy and apoptosis are redundantly required for C. elegans embryogenesis. Autophagy. 2011 May;7(5):557-9. Boulay G, Dubuissez M, Van Rechem C, Forget A, Helin K, Ayrault O, Leprince D. Hypermethylated in Cancer 1 (HIC1) Recruits Polycomb Repressive Complex 2 (PRC2) to a Subset of Its Target Genes through Interaction with Human Polycomb-like (hPCL) Proteins. J Biol Chem. 2012 Mar 23;287(13):10509-24. Bouwman P, Drost R, Klijn C, Pieterse M, van der Gulden H, Song JY, Szuhai K, Jonkers J. Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression. J Pathol. 2011 May;224(1):10-21. Brand S, Teich R, Dicke T, Harb H, Yildirim AÖ, Tost J, Schneider-Stock R, Waterland RA, Bauer UM, von Mutius E, Garn H, Pfefferle PI, Renz H. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol. 2011 Sep;128(3):618-25.e1-7. Brennan DJ, O'Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirström K, Gallagher WM. The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer. Oncogene. 2011 Dec 5. doi: 10.1038/onc.2011.519 Bug M, Dobbelstein M. Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms. Oncogene. 2011 Aug 18;30(33):3612-24. Blasius M, Forment JV, Thakkar N, Wagner SA, Choudhary C, Jackson SP. A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1. Genome Biol. 2011 Aug 18;12(8):R78. Bogurcu N., Sevimli-Gur C., Ozmen B., Bedir E., Korkmaz K.S., ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. Biochem Biophys Res Commun. 2011 Jun 17;409(4):738-44. Borsos E, Erdélyi P, Vellai T. Autophagy and apoptosis are redundantly required for C. elegans embryogenesis. Autophagy. 2011 May;7(5):557-9. Boulay G, Dubuissez M, Van Rechem C, Forget A, Helin K, Ayrault O, Leprince D. Hypermethylated in Cancer 1 (HIC1) Recruits Polycomb Repressive Complex 2 (PRC2) to a Subset of Its Target Genes through Interaction with Human Polycomb-like (hPCL) Proteins. J Biol Chem. 2012 Mar 23;287(13):10509-24. Bouwman P, Drost R, Klijn C, Pieterse M, van der Gulden H, Song JY, Szuhai K, Jonkers J. Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression. J Pathol. 2011 May;224(1):10-21. Brand S, Teich R, Dicke T, Harb H, Yildirim AÖ, Tost J, Schneider-Stock R, Waterland RA, Bauer UM, von Mutius E, Garn H, Pfefferle PI, Renz H. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol. 2011 Sep;128(3):618-25.e1-7. Brennan DJ, O'Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirström K, Gallagher WM. The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer. Oncogene. 2011 Dec 5. doi: 10.1038/onc.2011.519 Bug M, Dobbelstein M. Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms. Oncogene. 2011 Aug 18;30(33):3612-24. Bunting SF, Callen E, Kozak ML, Kim JM, Wong N, Lopez-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A. BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair. Mol Cell. 2012 Mar 20. [Epub ahead of print] Campaner S, Amati B. Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance. Cell Div. 2012 Feb 28;7(1):6. Campaner S, Spreafico F, Burgold T, Doni M, Rosato U, Amati B, Testa G. The methyltransferase Set7/9 (Setd7) is dispensable for the p53-mediated DNA damage response in vivo. Mol Cell. 2011 Aug 19;43(4):681-8. Chandler I, Houlston R, Landberg G. A practical guide to constructing and using tissue microarrays. Methods Mol Biol. 2011;675:363-73. Chatzakos V, Slätis K, Djureinovic T, Helleday T, Hunt MC. N-Acyl Taurines are Anti-Proliferative in Prostate Cancer Cells. Lipids. 2012 Apr;47(4):355-61. Chawla R, Redon S, Raftopoulou C, Wischnewski H, Gagos S, Azzalin CM. Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 2011 Aug 9;30(19):4047-58 Chau YY, Brownstein D, Mjoseng H, Lee WC, Buza-Vidas N, Nerlov C, Jacobsen SE, Perry P, Berry R, Thornburn A, Sexton D, Morton N, Hohenstein P, Freyer E, Samuel K, van't Hof R, Hastie N. Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1. PLoS Genet. 2011 Dec;7(12):e1002404. Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, Alitalo K, Lehti K, Ojala PM. KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host Microbe. 2011 Dec 15;10(6):577-90. Chilov D, Sinjushina N, Rita H, Taketo MM, Mäkelä TP, Partanen J. Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain. Dev Biol. 2011 Sep 1;357(1):259-68. Choi S, Toledo LI, Fernandez-Capetillo O, Bakkenist CJ. CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells. DNA Repair (Amst). 2011 Oct 10;10(10):1000-1. Christodoulou A, Kostakis IK, Kourafalos V, Pouli N, Marakos P, Trougakos IP, Tsitsilonis OE. Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles. Bioorg Med Chem Lett. 2011 May 15;21(10):3110-2. Ciampricotti M, Hau CS, Doornebal CW, Jonkers J, de Visser KE. Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system. Nat Med. 2012 Mar 6;18(3):344-6. Ciampricotti M, Vrijland K, Hau CS, Pemovska T, Doornebal CW, Speksnijder EN, Wartha K, Jonkers J, de Visser KE. Development of metastatic HER2(+) breastcancer is independent of the adaptive immune system. J Pathol. 2011 May;224(1):56-66. Collas P. A chromatin immunoprecipitation protocol for small cell numbers. Methods Mol Biol. 2011;791:179-93. Collas P. Notice of redundant publication. Nuclear reprogramming in cell-free extracts. Philos Trans R Soc Lond B Biol Sci. 2011 Nov 12;366(1581):3162. Craig AL, Moser SC, Bailly AP, Gartner A. Methods for studying the DNA damage response in the Caenorhabdatis elegans germ line. Methods Cell Biol. 2012;107:321-52. Daniels M, Lurkin I, Pauli R, Erbstösser E, Hildebrandt U, Hellwig K, Zschille U, Lüders P, Krüger G, Knolle J, Stengel B, Prall F, Hertel K, Lobeck H, Popp B, Theissig F, Wünsch P, Zwarthoff E, Agaimy A, Schneider-Stock R. Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST). Cancer Lett. 2011 Dec 15;312(1):43-54. de Jong J, de Ridder J, van der Weyden L, Sun N, van Uitert M, Berns A, van Lohuizen M, Jonkers J, Adams DJ, Wessels LF. Computational identification of insertional mutagenesis targets for cancer gene discovery. Nucleic Acids Res. 2011 Aug;39(15):e105. del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR. Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9. del Barco Barrantes I, Nebreda AR. Roles of p38 MAPKs in invasion and metastasis. Biochem Soc Trans. 2012 Feb 1;40(1):79-84. Dereli-Öz A, Versini G, Halazonetis TD. Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress.Mol Oncol. 2011 Aug;5(4):308-14 Derksen PW, Braumuller TM, van der Burg E, Hornsveld M, Mesman E, Wesselin J, Krimpenfort P, Jonkers J. Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis Model Mech. 2011 May;4(3):347-58. de Schepper J, Rasmussen MH, Gucev Z, Eliakim A, Battelino T. Long-acting pegylated human GH in children with GH deficiency: a single-dose, dose-escalation trial investigating safety, tolerability, pharmacokinetics and pharmacodynamics. Eur J Endocrinol. 2011 Sep;165(3):401-9 Devgan SS, Sanal O, Doil C, Nakamura K, Nahas SA, Pettijohn K, Bartek J, Lukas C, Lukas J, Gatti RA. Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death Differ. 2011 Sep;18(9):1500-6. DeWeese, T.L. and Laiho, M. (Editors) Molecular Determinants of Radiation Response. Springer, New York, NY. 2011, ISBN 978-1-4419-8043-4, 276 pages. Dimitrova P, Vassilev T, Shivarov V. Inhibition or overactivation of AICDA to eliminate pathologic B cell clones? Comment on the article by Hsu et al. Arthritis Rheum. 2011 Oct;63(10):3174-5; author reply 3175-7 Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol. 2011 Aug 22;194(4):567-79. Doubravska L, Krausova M, Gradl D, Vojtechova M, Tumova L, Lukas J, Valenta T, Pospichalova V, Fafilek B, Plachy J, Sebesta O, Korinek V. Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling. Cell Signal. 2011 May;23(5):837-48. Dreher A, Rossing M, Kaczkowski B, Andersen DK, Larsen TJ, Christophersen MK, Nielsen FC, Norrild B. Differential expression of cellular microRNAs in HPV 11, -16, and -45 transfected cells. Biochem Biophys Res Commun. 2011 Aug 19;412(1):20-5. Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S, Klijn C, van der Heijden I, van der Gulden H, Wientjens E, Pieterse M, Catteau A, Green P, Solomon E, Morris JR, Jonkers J. BRCA1 RING function is essential for tumorsuppression but dispensable for therapy resistance. Cancer Cell. 2011 Dec 13;20(6):797-809. Edrei Y, Gross E, Corchia N, Tsarfaty G, Galun E, Pappo O, Abramovitch R. Vascular profile characterization of liver tumors by magnetic resonance imaging using hemodynamic response imaging in mice. Neoplasia. 2011 Mar;13(3):244-53. Elvers I, Johansson F, Groth P, Erixon K, Helleday T. UV stalled replication forks restart by re-priming in human fibroblasts. Nucleic Acids Res. 2011 Sep 1;39(16):7049-57 Emamzadah S, Tropia L, Halazonetis TD. Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element. Mol Cancer Res. 2011 Nov;9(11):1493-9. Erbaykent-Tepedelen B., Özmen B., Varisli L., Gonen-Korkmaz C., Debelec-Butuner B., Syed M.H., Yilmazer-Cakmak O., Korkmaz K.S., NKX3.1 contributes to S phase entry and regulates DNA damage response (DDR) in prostate cancer cell lines. Biochem Biophys Res Commun. 2011 Sep 12; 414 (1):123-128 Ermakova O, Piszczek L, Luciani L, Cavalli FM, Ferreira T, Farley D, Rizzo S, Paolicelli RC, Al-Banchaabouchi M, Nerlov C, Moriggl R, Luscombe NM, Gross C. Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med. 2011 Jan;3(1):50-66. Fandridis E, Apergis G, Korres DS, Nikolopoulos K, Zoubos AB, Papassideri I, Trougakos IP. Increased expression levels of apolipoprotein J/clusterin during primary osteoarthritis. In Vivo. 2011 Sep-Oct;25(5):745-9. Farkas IJ, Korcsmáros T, Kovács IA, Mihalik Á, Palotai R, Simkó GI, Szalay KZ, Szalay-Beko M, Vellai T, Wang S, Csermely P. Network-based tools for the identification of novel drug targets. Sci Signal. 2011 May 17;4(173):pt3. Ferk F, Chakraborty A, Jäger W, Kundi M, Bichler J, Mišík M, Wagner KH, Grasl-Kraupp B, Sagmeister S, Haidinger G, Hoelzl C, Nersesyan A, Dušinská M, Simić T, Knasmüller S. Potent protection of gallic acid against DNA oxidation: results of human and animal experiments. Mutat Res. 2011 Oct 1;715(1-2):61-71. Flott S, Kwon Y, Pigli YZ, Rice PA, Sung P, Jackson SP. Regulation of Rad51 function by phosphorylation. EMBO Rep. 2011 Jul 8;12(8):833-9. Follin-Arbelet V, Hofgaard PO, Hauglin H, Naderi S, Sundan A, Blomhoff R, Bogen B, Blomhoff HK. Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model. BMC Cancer. 2011 Jul 18;11:301. Forment JV, Blasius M, Guerini I, Jackson SP. Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation. PLoS One. 2011;6(8):e23517 Franz A, Orth M, Pirson PA, Sonneville R, Blow JJ, Gartner A, Stemmann O, Hoppe T. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell. 2011 Oct 7;44(1):85-96. Fraser M, Zhao H, Luoto KR, Lundin C, Coackley C, Chan N, Joshua AM, Bismar TA, Evans A, Helleday T, Bristow RG. PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy. Clin Cancer Res. 2012 Feb 15;18(4):1015-27. Fredly H, Ersvær E, Gjertsen BT, Bruserud O. Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis. Oncol Rep. 2011 Jun;25(6):1549-56. Fredly H, Reikvam H, Gjertsen BT, Bruserud O. 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